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- W2004671875 abstract "Abstract Fasting and refeeding rats on a glucose-casein diet increased both the activity of glucose 6-phosphate dehydrogenase and the conversion of glucose into fatty acids in liver, whereas refeeding on glucose alone caused a comparable rise in the lipogenic rate without altering the dehydrogenase activity, indicating that the induced levels of the dehydrogenase are not necessarily required for the increased generation of NADPH under the adaptive hyperlipogenesis. This was partially proved by the finding that the oxidation of carbon 1 of glucose was preferentially increased over carbon 6 in the liver of glucose-refed rats. The activities of malic enzyme, citrate cleavage enzyme and glucokinase were elevated substantially by refeeding glucose with or without added protein. These results were interpreted as indicating that the response of enzymes catalyzing the carbon chain-supplying reactions in fatty acid synthesis from glucose is of a primary importance for the adaptive hyperlipogenesis and that the induction of glucose 6-phosphate dehydrogenase by the glucose-casein diet is rather representing a metabolic consequence secondary to the enhanced fatty acid synthesis." @default.
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- W2004671875 date "1970-12-01" @default.
- W2004671875 modified "2023-09-26" @default.
- W2004671875 title "Differential responses of glucose 6-phosphate dehydrogenase and lipogenesis to fat-free diets" @default.
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- W2004671875 doi "https://doi.org/10.1016/0006-2944(70)90082-7" @default.
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