FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004671917> ?p ?o ?g. }

• W2004671917 endingPage "461" @default.
• W2004671917 startingPage "456" @default.
• W2004671917 abstract "Trough (C0) monitoring is not optimal for therapeutic drug monitoring of tacrolimus. To better estimate systemic exposure of tacrolimus and achieve clinical benefit, an improved therapeutic drug monitoring strategy should be developed. The authors examined which single and combination of time points best estimated the empiric “gold standard” AUC0-12h and developed and validated a new, flexible, and accurate limited sampling model for monitoring tacrolimus in patients having undergone liver transplantation. Twenty-three stable patients with full AUC0-12h were divided into two groups based on area under the concentration-time curve/dose. With multiple regression analysis, limited sampling formulae were derived and population-pharmacokinetic-based limited sampling models were developed and validated. A regression analysis was performed between either area under the concentration-time curves calculated with formulae or models with the reference trapezoidal AUC0-12h. Both formulae and models based on single samples C4-C6 (r2 = 0.94 [MPE/MAPE 0/7]-0.90 [2/8] and 0.97 [0/7]-0.97 [1/5]) showed excellent performance. The calculated area under the concentration-time curve target range for tacrolimus was 90 to 130 h*μg/L. Multiple point sampling performed better, especially when using models (r2 > 0.94). C0 was a less precise predictor of AUC0-12h compared with both formulae and models (r2's 0.68 [5/17] and 0.87 [2/14]). In conclusion, trough concentration monitoring is not an accurate method for assessing systemic exposure to tacrolimus in stable patients having undergone liver transplantation. This new limited sampling model, based on single time points C4-C6, shows excellent performance in estimating the AUC0-12h." @default.
• W2004671917 created "2016-06-24" @default.
• W2004671917 creator A5008043617 @default.
• W2004671917 creator A5011081386 @default.
• W2004671917 creator A5030434830 @default.
• W2004671917 creator A5034348684 @default.
• W2004671917 creator A5051041238 @default.
• W2004671917 creator A5062500498 @default.
• W2004671917 creator A5079248792 @default.
• W2004671917 creator A5087233004 @default.
• W2004671917 date "2008-08-01" @default.
• W2004671917 modified "2023-10-16" @default.
• W2004671917 title "Flexible Limited Sampling Model for Monitoring Tacrolimus in Stable Patients Having Undergone Liver Transplantation With Samples 4 to 6 Hours After Dosing Is Superior to Trough Concentration" @default.
• W2004671917 cites W1968221146 @default.
• W2004671917 cites W1980689918 @default.
• W2004671917 cites W1980932961 @default.
• W2004671917 cites W1989480016 @default.
• W2004671917 cites W1992056800 @default.
• W2004671917 cites W1992886649 @default.
• W2004671917 cites W1995279440 @default.
• W2004671917 cites W2003143162 @default.
• W2004671917 cites W2018857408 @default.
• W2004671917 cites W2021544053 @default.
• W2004671917 cites W2027275750 @default.
• W2004671917 cites W2035276049 @default.
• W2004671917 cites W2045109635 @default.
• W2004671917 cites W2054542336 @default.
• W2004671917 cites W2057336128 @default.
• W2004671917 cites W2062506346 @default.
• W2004671917 cites W2068650301 @default.
• W2004671917 cites W2072098181 @default.
• W2004671917 cites W2072296662 @default.
• W2004671917 cites W2079402257 @default.
• W2004671917 cites W2082043357 @default.
• W2004671917 cites W2094287284 @default.
• W2004671917 cites W2096799462 @default.
• W2004671917 cites W2148973525 @default.
• W2004671917 cites W2165071403 @default.
• W2004671917 cites W2331816066 @default.
• W2004671917 cites W4249306916 @default.
• W2004671917 doi "https://doi.org/10.1097/ftd.0b013e31818162b9" @default.
• W2004671917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18641539" @default.
• W2004671917 hasPublicationYear "2008" @default.
• W2004671917 type Work @default.
• W2004671917 sameAs 2004671917 @default.
• W2004671917 citedByCount "17" @default.
• W2004671917 countsByYear W20046719172012 @default.
• W2004671917 countsByYear W20046719172013 @default.
• W2004671917 countsByYear W20046719172014 @default.
• W2004671917 countsByYear W20046719172015 @default.
• W2004671917 countsByYear W20046719172016 @default.
• W2004671917 countsByYear W20046719172019 @default.
• W2004671917 countsByYear W20046719172022 @default.
• W2004671917 countsByYear W20046719172023 @default.
• W2004671917 crossrefType "journal-article" @default.
• W2004671917 hasAuthorship W2004671917A5008043617 @default.
• W2004671917 hasAuthorship W2004671917A5011081386 @default.
• W2004671917 hasAuthorship W2004671917A5030434830 @default.
• W2004671917 hasAuthorship W2004671917A5034348684 @default.
• W2004671917 hasAuthorship W2004671917A5051041238 @default.
• W2004671917 hasAuthorship W2004671917A5062500498 @default.
• W2004671917 hasAuthorship W2004671917A5079248792 @default.
• W2004671917 hasAuthorship W2004671917A5087233004 @default.
• W2004671917 hasConcept C105795698 @default.
• W2004671917 hasConcept C106131492 @default.
• W2004671917 hasConcept C112705442 @default.
• W2004671917 hasConcept C126322002 @default.
• W2004671917 hasConcept C126894567 @default.
• W2004671917 hasConcept C140779682 @default.
• W2004671917 hasConcept C141071460 @default.
• W2004671917 hasConcept C2777288759 @default.
• W2004671917 hasConcept C2779609443 @default.
• W2004671917 hasConcept C2780272996 @default.
• W2004671917 hasConcept C2908647359 @default.
• W2004671917 hasConcept C2909675724 @default.
• W2004671917 hasConcept C2910800852 @default.
• W2004671917 hasConcept C2911091166 @default.
• W2004671917 hasConcept C31785415 @default.
• W2004671917 hasConcept C31972630 @default.
• W2004671917 hasConcept C33923547 @default.
• W2004671917 hasConcept C41008148 @default.
• W2004671917 hasConcept C48921125 @default.
• W2004671917 hasConcept C71924100 @default.
• W2004671917 hasConcept C76318530 @default.
• W2004671917 hasConcept C99454951 @default.
• W2004671917 hasConceptScore W2004671917C105795698 @default.
• W2004671917 hasConceptScore W2004671917C106131492 @default.
• W2004671917 hasConceptScore W2004671917C112705442 @default.
• W2004671917 hasConceptScore W2004671917C126322002 @default.
• W2004671917 hasConceptScore W2004671917C126894567 @default.
• W2004671917 hasConceptScore W2004671917C140779682 @default.
• W2004671917 hasConceptScore W2004671917C141071460 @default.
• W2004671917 hasConceptScore W2004671917C2777288759 @default.
• W2004671917 hasConceptScore W2004671917C2779609443 @default.
• W2004671917 hasConceptScore W2004671917C2780272996 @default.
• W2004671917 hasConceptScore W2004671917C2908647359 @default.
• W2004671917 hasConceptScore W2004671917C2909675724 @default.
• W2004671917 hasConceptScore W2004671917C2910800852 @default.

• next