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• W2004672286 abstract "The effects of hematopoietic cytokines on the expression of transforming growth factors (TGF beta) mRNA and the effect of TGF beta on cytokine and on a major extracellular matrix protein, collagen I, mRNA expression was studied in human marrow stromal cells. As with other cultured mesenchymal cells, stromal cells constitutively express TGF beta 1 but not TGF alpha mRNA. In simian virus 40 (SV40)-transformed stromal cells downregulation of TGF beta 1 expression was observed 2 hours after incubation with recombinant human (rh) tumor-necrosis factor alpha (TNF alpha) and 144 h after addition of rh granulocyte macrophage colony-stimulating factor (GM-CSF). Neither interleukin-1 (IL-1)beta nor IL-6 had an observable effect on TGF beta 1 mRNA expression. TGF beta upregulated collagen I mRNA expression. These data suggest that cytokines may influence TGF beta mRNA expression." @default.
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• W2004672286 date "2009-04-24" @default.
• W2004672286 modified "2023-10-17" @default.
• W2004672286 title "Transforming growth factor β expression in human marrow stromal cells" @default.
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• W2004672286 doi "https://doi.org/10.1111/j.1600-0609.1991.tb01267.x" @default.
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