FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004672785> ?p ?o ?g. }

• W2004672785 endingPage "481" @default.
• W2004672785 startingPage "469" @default.
• W2004672785 abstract "Helicobacter pylori is a helical bacterium that colonizes the stomach in over half of the world's population. Infection with this bacterium has been linked to peptic ulcer disease and gastric cancer. The bacterium has been shown to affect regulatory pathways in its host cells through specific virulence factors that control gene expression. Infection with H. pylori increases levels of phosphorylation of Raf kinase inhibitor protein (pRKIP) in gastric adenocarcinoma (AGS) cells in vitro and in vivo. We investigated the role of H. pylori in the phosphorylation of RKIP as a possible mechanism to downregulate pro-survival signals in gastric adenocarcinoma. pRKIP induces RKIP transcriptional activity, which serves to induce apoptosis of damaged cells to prevent further tumorigenesis. Infection of wild type and RKIP knockout mice with H. pylori for 2 months further confirmed roles of RKIP and pRKIP in the prevention of gastric cancer progression. Loss of RKIP in AGS cells results in increased expression of the Cag A virulence factor after H. pylori infection and RKIP overexpression inhibits H. pylori-mediated STAT3 phosphorylation and STAT3 and NF-κB transcriptional activity. We examined the role of mTOR (mammalian target of rapamycin) after H. pylori infection on the phosphorylation of RKIP. Cells treated with rapamycin, an inhibitor of mTOR, displayed less expression of pRKIP after H. pylori infection. Microarray antibody analysis was conducted on wild-type and RKIP-knockdown AGS cells and showed that in the absence of RKIP, there was increased expression of pro-tumorigenic proteins such as EGFR, Raf-1, and MAPKs. Although further work is needed to confirm the interaction of RKIP and mTOR in AGS cells as a result of H. pylori infection, we hypothesize that H. pylori-mediated induction of pro-survival signaling in gastric epithelial cells induces a feedback response through the activation of RKIP. The phosphorylated, or active, form of RKIP is important in protecting gastric epithelial cells from tumorigenesis after H. pylori infection." @default.
• W2004672785 created "2016-06-24" @default.
• W2004672785 creator A5030339238 @default.
• W2004672785 creator A5037913954 @default.
• W2004672785 creator A5046883603 @default.
• W2004672785 creator A5047813288 @default.
• W2004672785 creator A5055073191 @default.
• W2004672785 creator A5059564546 @default.
• W2004672785 date "2014-01-01" @default.
• W2004672785 modified "2023-09-27" @default.
• W2004672785 title "Role of Raf Kinase Inhibitor Protein in Helicobacter pylori-Mediated Signaling in Gastric Cancer" @default.
• W2004672785 cites W1969330410 @default.
• W2004672785 cites W1969832654 @default.
• W2004672785 cites W1977688298 @default.
• W2004672785 cites W1977793644 @default.
• W2004672785 cites W1977983659 @default.
• W2004672785 cites W1986408860 @default.
• W2004672785 cites W1993338076 @default.
• W2004672785 cites W2005496215 @default.
• W2004672785 cites W2025476651 @default.
• W2004672785 cites W2037159785 @default.
• W2004672785 cites W2044227662 @default.
• W2004672785 cites W2052835061 @default.
• W2004672785 cites W2059287377 @default.
• W2004672785 cites W2062652279 @default.
• W2004672785 cites W2071289226 @default.
• W2004672785 cites W2083608706 @default.
• W2004672785 cites W2084121895 @default.
• W2004672785 cites W2089185822 @default.
• W2004672785 cites W2106435751 @default.
• W2004672785 cites W2106510242 @default.
• W2004672785 cites W2107436171 @default.
• W2004672785 cites W2121640179 @default.
• W2004672785 cites W2126934083 @default.
• W2004672785 cites W2128000228 @default.
• W2004672785 cites W2135803007 @default.
• W2004672785 cites W2142242441 @default.
• W2004672785 cites W2142308379 @default.
• W2004672785 cites W2146415848 @default.
• W2004672785 cites W2164363164 @default.
• W2004672785 cites W2168410023 @default.
• W2004672785 cites W2170966889 @default.
• W2004672785 cites W2320937221 @default.
• W2004672785 cites W2405482376 @default.
• W2004672785 doi "https://doi.org/10.1615/critrevoncog.2014012044" @default.
• W2004672785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5755693" @default.
• W2004672785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25597356" @default.
• W2004672785 hasPublicationYear "2014" @default.
• W2004672785 type Work @default.
• W2004672785 sameAs 2004672785 @default.
• W2004672785 citedByCount "11" @default.
• W2004672785 countsByYear W20046727852015 @default.
• W2004672785 countsByYear W20046727852016 @default.
• W2004672785 countsByYear W20046727852017 @default.
• W2004672785 countsByYear W20046727852018 @default.
• W2004672785 countsByYear W20046727852021 @default.
• W2004672785 countsByYear W20046727852023 @default.
• W2004672785 crossrefType "journal-article" @default.
• W2004672785 hasAuthorship W2004672785A5030339238 @default.
• W2004672785 hasAuthorship W2004672785A5037913954 @default.
• W2004672785 hasAuthorship W2004672785A5046883603 @default.
• W2004672785 hasAuthorship W2004672785A5047813288 @default.
• W2004672785 hasAuthorship W2004672785A5055073191 @default.
• W2004672785 hasAuthorship W2004672785A5059564546 @default.
• W2004672785 hasBestOaLocation W20046727852 @default.
• W2004672785 hasConcept C104317684 @default.
• W2004672785 hasConcept C11960822 @default.
• W2004672785 hasConcept C121608353 @default.
• W2004672785 hasConcept C173396325 @default.
• W2004672785 hasConcept C184235292 @default.
• W2004672785 hasConcept C190283241 @default.
• W2004672785 hasConcept C2776409635 @default.
• W2004672785 hasConcept C2778204961 @default.
• W2004672785 hasConcept C2778923194 @default.
• W2004672785 hasConcept C502942594 @default.
• W2004672785 hasConcept C54355233 @default.
• W2004672785 hasConcept C55493867 @default.
• W2004672785 hasConcept C555283112 @default.
• W2004672785 hasConcept C60987743 @default.
• W2004672785 hasConcept C62478195 @default.
• W2004672785 hasConcept C86554907 @default.
• W2004672785 hasConcept C86803240 @default.
• W2004672785 hasConcept C95444343 @default.
• W2004672785 hasConceptScore W2004672785C104317684 @default.
• W2004672785 hasConceptScore W2004672785C11960822 @default.
• W2004672785 hasConceptScore W2004672785C121608353 @default.
• W2004672785 hasConceptScore W2004672785C173396325 @default.
• W2004672785 hasConceptScore W2004672785C184235292 @default.
• W2004672785 hasConceptScore W2004672785C190283241 @default.
• W2004672785 hasConceptScore W2004672785C2776409635 @default.
• W2004672785 hasConceptScore W2004672785C2778204961 @default.
• W2004672785 hasConceptScore W2004672785C2778923194 @default.
• W2004672785 hasConceptScore W2004672785C502942594 @default.
• W2004672785 hasConceptScore W2004672785C54355233 @default.
• W2004672785 hasConceptScore W2004672785C55493867 @default.
• W2004672785 hasConceptScore W2004672785C555283112 @default.
• W2004672785 hasConceptScore W2004672785C60987743 @default.
• W2004672785 hasConceptScore W2004672785C62478195 @default.

• next