FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004673957> ?p ?o ?g. }

• W2004673957 endingPage "19553" @default.
• W2004673957 startingPage "19553" @default.
• W2004673957 abstract "Introduction Lipodystrophy is still a matter of concern in HIV+ patients receiving ART. However, long-term fat change in patients taking non-thymidine regimens is not well known. Materials and Methods A prospective ongoing fat change assessment including clinical evaluation and dexa scans (Hologic QDR 4500) is being conducted in all consecutive patients initiating ART from January 2008. Arm, leg, trunk and total fat as well as fat mass ratio (FMR=% trunk fat/% leg fat) were determined. Patients with data at baseline (BL), 12 and 36 m are included in this analysis. ITT and OT were performed. Multivariate general linear models were used to assess changes in fat measures. Results One hundred patients were included. 81% men, 42.9 years, 18% AIDS, CD4 218.5 (6-756), viral load 5 log (2.9-6.8), leg fat 4644g, trunk fat 6693g, FMR 0.94. Around 40 patients (40%) initiated a PIr (17 LPVr, 11 ATVr, 9 DRVr, 3 FPVr), 34 (34%) NVP and 21 (21%) EFV. About 83% received TDF/FTC and 10% ABC/3TC. Groups were comparable at BL except for a lower viral load in NVP patients (p=0.047) and lower c-LDL in PI patients (p=0.043). After 36 m, no patient presented a clinically evident lipodystrophy. At 12 m, an overall significant increase was found from baseline in trunk, leg and FMR (median 759 g, 479.4 g and 0.03, respectively, p<0.05) and at 36 m in trunk and leg fat (median 989.9 g, 566 g, respectively, p<0.05). According to ART, at 12 m a significant increase in trunk and leg fat was observed in EFV and PIr. At 36 m, in NVP patients trunk and leg fat as well as FMR increased, whereas in PIr patients only leg fat increased (see figure). In ITT analysis, adjusted by age, sex, risk practice and BL CD4, EFV was associated with a greater increase in FMR (p=0.036) at 36 m vs PIr. In OT analysis, at 12 m, NVP was associated with a smaller percentage increase in trunk fat (vs PIr and EFV, p=0.006) and in leg fat (vs PIr, p=0.046). These differences did not persist at 36 m. Conclusions In this cohort of patients taking non-thymidine-based regimens, after 36 m without a clinically evident lipodystrophy, no significant changes in FMR were observed. However, some differences in fat redistribution according to ART were present: PIr was associated with an initial and continuous increase in trunk and leg fat, NVP with a slower and progressive increase in both fat compartments, while in EFV patients, the initial fat increase was followed by a decrease in peripheral fat at 36 m. Longer follow up will help to confirm these trends." @default.
• W2004673957 created "2016-06-24" @default.
• W2004673957 creator A5001557481 @default.
• W2004673957 creator A5005132007 @default.
• W2004673957 creator A5012384912 @default.
• W2004673957 creator A5020210842 @default.
• W2004673957 creator A5033564270 @default.
• W2004673957 creator A5040675878 @default.
• W2004673957 creator A5053140952 @default.
• W2004673957 creator A5053844368 @default.
• W2004673957 creator A5056571820 @default.
• W2004673957 creator A5089992675 @default.
• W2004673957 date "2014-11-01" @default.
• W2004673957 modified "2023-10-05" @default.
• W2004673957 title "Long-term fat redistribution in ARV-naïve HIV+ patients initiating a non-thymidine containing regimen in clinical practice" @default.
• W2004673957 doi "https://doi.org/10.7448/ias.17.4.19553" @default.
• W2004673957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224890" @default.
• W2004673957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25394060" @default.
• W2004673957 hasPublicationYear "2014" @default.
• W2004673957 type Work @default.
• W2004673957 sameAs 2004673957 @default.
• W2004673957 citedByCount "0" @default.
• W2004673957 crossrefType "journal-article" @default.
• W2004673957 hasAuthorship W2004673957A5001557481 @default.
• W2004673957 hasAuthorship W2004673957A5005132007 @default.
• W2004673957 hasAuthorship W2004673957A5012384912 @default.
• W2004673957 hasAuthorship W2004673957A5020210842 @default.
• W2004673957 hasAuthorship W2004673957A5033564270 @default.
• W2004673957 hasAuthorship W2004673957A5040675878 @default.
• W2004673957 hasAuthorship W2004673957A5053140952 @default.
• W2004673957 hasAuthorship W2004673957A5053844368 @default.
• W2004673957 hasAuthorship W2004673957A5056571820 @default.
• W2004673957 hasAuthorship W2004673957A5089992675 @default.
• W2004673957 hasBestOaLocation W20046739571 @default.
• W2004673957 hasConcept C126322002 @default.
• W2004673957 hasConcept C141071460 @default.
• W2004673957 hasConcept C142462285 @default.
• W2004673957 hasConcept C188816634 @default.
• W2004673957 hasConcept C18903297 @default.
• W2004673957 hasConcept C203014093 @default.
• W2004673957 hasConcept C2780941825 @default.
• W2004673957 hasConcept C2781197403 @default.
• W2004673957 hasConcept C2781413609 @default.
• W2004673957 hasConcept C2993143319 @default.
• W2004673957 hasConcept C3013748606 @default.
• W2004673957 hasConcept C71924100 @default.
• W2004673957 hasConcept C86803240 @default.
• W2004673957 hasConcept C90924648 @default.
• W2004673957 hasConceptScore W2004673957C126322002 @default.
• W2004673957 hasConceptScore W2004673957C141071460 @default.
• W2004673957 hasConceptScore W2004673957C142462285 @default.
• W2004673957 hasConceptScore W2004673957C188816634 @default.
• W2004673957 hasConceptScore W2004673957C18903297 @default.
• W2004673957 hasConceptScore W2004673957C203014093 @default.
• W2004673957 hasConceptScore W2004673957C2780941825 @default.
• W2004673957 hasConceptScore W2004673957C2781197403 @default.
• W2004673957 hasConceptScore W2004673957C2781413609 @default.
• W2004673957 hasConceptScore W2004673957C2993143319 @default.
• W2004673957 hasConceptScore W2004673957C3013748606 @default.
• W2004673957 hasConceptScore W2004673957C71924100 @default.
• W2004673957 hasConceptScore W2004673957C86803240 @default.
• W2004673957 hasConceptScore W2004673957C90924648 @default.
• W2004673957 hasLocation W20046739571 @default.
• W2004673957 hasLocation W20046739572 @default.
• W2004673957 hasLocation W20046739573 @default.
• W2004673957 hasLocation W20046739574 @default.
• W2004673957 hasLocation W20046739575 @default.
• W2004673957 hasOpenAccess W2004673957 @default.
• W2004673957 hasPrimaryLocation W20046739571 @default.
• W2004673957 hasRelatedWork W1969969939 @default.
• W2004673957 hasRelatedWork W2031699218 @default.
• W2004673957 hasRelatedWork W2047967234 @default.
• W2004673957 hasRelatedWork W2058489177 @default.
• W2004673957 hasRelatedWork W2092811583 @default.
• W2004673957 hasRelatedWork W2147929783 @default.
• W2004673957 hasRelatedWork W3010145548 @default.
• W2004673957 hasRelatedWork W4298484041 @default.
• W2004673957 hasRelatedWork W592798118 @default.
• W2004673957 hasRelatedWork W1646022904 @default.
• W2004673957 hasVolume "17" @default.
• W2004673957 isParatext "false" @default.
• W2004673957 isRetracted "false" @default.
• W2004673957 magId "2004673957" @default.
• W2004673957 workType "article" @default.