Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004675263> ?p ?o ?g. }
- W2004675263 endingPage "334" @default.
- W2004675263 startingPage "325" @default.
- W2004675263 abstract "Bisphosphonates are widely used for the treatment of bone pathologies, mainly due to their ability to inhibit osteoclastic activity and thus bone resorption. Yet, their potential effect on bone formation is unclear. Our aim was to determine whether risedronate can affect osteoblastic differentiation of mesenchymal stromal cells (MSC).We evaluated the effect of the risedronate, which is a bisphosphonate widely used in clinical settings, on the differentiation of precursor cells of osteoblasts and adipocytes. Thus, MSC from human bone marrow were induced to differentiate into osteoblasts or adipocytes in the presence or absence of two risedronate concentrations (10⁻⁸ M and 10⁻⁹ M).Risedronate increased the levels of osteogenic markers including the extracellular matrix mineralization on cells induced to osteoblasts. On the other hand, such bisphosphonates did not have significant effects on the pparγ2 and lpl adipogenic genes or the fat vesicle accumulation on the cells induced into adipocytes. In addition, it increased the expression of early osteogenic differentiation genes like runx2 on MSC not induced to differentiate.Risedronate concentrations used favor the osteogenic differentiation and the MSC commitment towards osteoblasts. This suggests the possibility of using this bisphosphonate in cyclic bone treatments with anabolic drugs, enhancing the effect of the latter via a previous MSC commitment to preosteoblasts." @default.
- W2004675263 created "2016-06-24" @default.
- W2004675263 creator A5012784156 @default.
- W2004675263 creator A5052316311 @default.
- W2004675263 creator A5062541403 @default.
- W2004675263 creator A5064939347 @default.
- W2004675263 date "2013-07-01" @default.
- W2004675263 modified "2023-09-26" @default.
- W2004675263 title "Risedronate Positively Affects Osteogenic Differentiation of Human Mesenchymal Stromal Cells" @default.
- W2004675263 cites W1964755289 @default.
- W2004675263 cites W1968557485 @default.
- W2004675263 cites W1972906830 @default.
- W2004675263 cites W1975107690 @default.
- W2004675263 cites W1987469940 @default.
- W2004675263 cites W1989314537 @default.
- W2004675263 cites W1990792003 @default.
- W2004675263 cites W1993515428 @default.
- W2004675263 cites W2002395215 @default.
- W2004675263 cites W2006296519 @default.
- W2004675263 cites W2006730988 @default.
- W2004675263 cites W2007638378 @default.
- W2004675263 cites W2009100319 @default.
- W2004675263 cites W2017907565 @default.
- W2004675263 cites W2024299200 @default.
- W2004675263 cites W2024941123 @default.
- W2004675263 cites W2032719886 @default.
- W2004675263 cites W2032898149 @default.
- W2004675263 cites W2034934896 @default.
- W2004675263 cites W2067903474 @default.
- W2004675263 cites W2070793750 @default.
- W2004675263 cites W2071426740 @default.
- W2004675263 cites W2076064293 @default.
- W2004675263 cites W2077977728 @default.
- W2004675263 cites W2080682330 @default.
- W2004675263 cites W2084865918 @default.
- W2004675263 cites W2086939643 @default.
- W2004675263 cites W2089602036 @default.
- W2004675263 cites W2094905264 @default.
- W2004675263 cites W2110466791 @default.
- W2004675263 cites W2113162921 @default.
- W2004675263 cites W2126166859 @default.
- W2004675263 cites W2128801226 @default.
- W2004675263 cites W2134304734 @default.
- W2004675263 cites W2159999899 @default.
- W2004675263 cites W2169305616 @default.
- W2004675263 cites W2172170054 @default.
- W2004675263 cites W4234431721 @default.
- W2004675263 doi "https://doi.org/10.1016/j.arcmed.2013.05.002" @default.
- W2004675263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23867791" @default.
- W2004675263 hasPublicationYear "2013" @default.
- W2004675263 type Work @default.
- W2004675263 sameAs 2004675263 @default.
- W2004675263 citedByCount "18" @default.
- W2004675263 countsByYear W20046752632014 @default.
- W2004675263 countsByYear W20046752632015 @default.
- W2004675263 countsByYear W20046752632016 @default.
- W2004675263 countsByYear W20046752632017 @default.
- W2004675263 countsByYear W20046752632018 @default.
- W2004675263 countsByYear W20046752632019 @default.
- W2004675263 countsByYear W20046752632020 @default.
- W2004675263 countsByYear W20046752632021 @default.
- W2004675263 countsByYear W20046752632022 @default.
- W2004675263 countsByYear W20046752632023 @default.
- W2004675263 crossrefType "journal-article" @default.
- W2004675263 hasAuthorship W2004675263A5012784156 @default.
- W2004675263 hasAuthorship W2004675263A5052316311 @default.
- W2004675263 hasAuthorship W2004675263A5062541403 @default.
- W2004675263 hasAuthorship W2004675263A5064939347 @default.
- W2004675263 hasConcept C122927707 @default.
- W2004675263 hasConcept C126322002 @default.
- W2004675263 hasConcept C134018914 @default.
- W2004675263 hasConcept C16930146 @default.
- W2004675263 hasConcept C185592680 @default.
- W2004675263 hasConcept C189165786 @default.
- W2004675263 hasConcept C198826908 @default.
- W2004675263 hasConcept C202751555 @default.
- W2004675263 hasConcept C2776363554 @default.
- W2004675263 hasConcept C2776541429 @default.
- W2004675263 hasConcept C2777251235 @default.
- W2004675263 hasConcept C2778260815 @default.
- W2004675263 hasConcept C502942594 @default.
- W2004675263 hasConcept C55493867 @default.
- W2004675263 hasConcept C673006 @default.
- W2004675263 hasConcept C71924100 @default.
- W2004675263 hasConcept C86803240 @default.
- W2004675263 hasConcept C95444343 @default.
- W2004675263 hasConceptScore W2004675263C122927707 @default.
- W2004675263 hasConceptScore W2004675263C126322002 @default.
- W2004675263 hasConceptScore W2004675263C134018914 @default.
- W2004675263 hasConceptScore W2004675263C16930146 @default.
- W2004675263 hasConceptScore W2004675263C185592680 @default.
- W2004675263 hasConceptScore W2004675263C189165786 @default.
- W2004675263 hasConceptScore W2004675263C198826908 @default.
- W2004675263 hasConceptScore W2004675263C202751555 @default.
- W2004675263 hasConceptScore W2004675263C2776363554 @default.
- W2004675263 hasConceptScore W2004675263C2776541429 @default.
- W2004675263 hasConceptScore W2004675263C2777251235 @default.
- W2004675263 hasConceptScore W2004675263C2778260815 @default.