FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004676972> ?p ?o ?g. }

• W2004676972 abstract "The identification of novel genes involved in colorectal cancerogenesis is of high clinical relevance for early diagnosis, applying new therapeutic strategies and monitoring disease recurrence, in order to reduce disease incidence and mortality. Gene silencing through CpG island hypermethylation is a major epigenetic mechanism involved in cancer development. In our study, we aimed to identify and validate novel genes with a tumour specific DNA methylation profile in colorectal cancer. We performed a whole-genome methylation scan and identified several possible candidate genes that are hypermethylated in tumour in comparison to healthy colon mucosa. Using methylation-specific high-resolution melting analysis in a set consisting of 133 colorectal cancer samples, we were able to confirm an altered CpG site in TMEM25 in 69.2% (92/133) tumours analysed. Furthermore, the expression of TMEM25 was found to be significantly lower in tumour tissue. An inverse correlation between hypermethylation of TMEM25 and TMEM25 down-regulated expression was observed. Our results suggest that epigenetic down-regulation of TMEM25 is cancer-related; we thus suggest that TMEM25 hypermethylation might play a significant role in altering expression of this gene in colorectal cancer." @default.
• W2004676972 created "2016-06-24" @default.
• W2004676972 creator A5025568931 @default.
• W2004676972 creator A5033251076 @default.
• W2004676972 creator A5042945020 @default.
• W2004676972 creator A5048805964 @default.
• W2004676972 creator A5063085953 @default.
• W2004676972 date "2013-01-01" @default.
• W2004676972 modified "2023-09-23" @default.
• W2004676972 title "TMEM25 is a candidate biomarker methylated and down-regulated in colorectal cancer." @default.
• W2004676972 cites W136458434 @default.
• W2004676972 cites W1965262464 @default.
• W2004676972 cites W1975476791 @default.
• W2004676972 cites W1986149419 @default.
• W2004676972 cites W1994322947 @default.
• W2004676972 cites W1994473465 @default.
• W2004676972 cites W1996777571 @default.
• W2004676972 cites W2009126524 @default.
• W2004676972 cites W2015908736 @default.
• W2004676972 cites W2017502278 @default.
• W2004676972 cites W2027102338 @default.
• W2004676972 cites W2040835684 @default.
• W2004676972 cites W2045928514 @default.
• W2004676972 cites W2049685139 @default.
• W2004676972 cites W2051705329 @default.
• W2004676972 cites W2057769740 @default.
• W2004676972 cites W2061390323 @default.
• W2004676972 cites W2065914817 @default.
• W2004676972 cites W2075658137 @default.
• W2004676972 cites W2078261763 @default.
• W2004676972 cites W2078727419 @default.
• W2004676972 cites W2082594247 @default.
• W2004676972 cites W2094224769 @default.
• W2004676972 cites W2096099115 @default.
• W2004676972 cites W2097998761 @default.
• W2004676972 cites W2098442878 @default.
• W2004676972 cites W2101170994 @default.
• W2004676972 cites W2102714937 @default.
• W2004676972 cites W2105423509 @default.
• W2004676972 cites W2114570899 @default.
• W2004676972 cites W2128146359 @default.
• W2004676972 cites W2137286268 @default.
• W2004676972 cites W2141105144 @default.
• W2004676972 cites W2154719999 @default.
• W2004676972 cites W2162813066 @default.
• W2004676972 cites W2163125553 @default.
• W2004676972 cites W2169903102 @default.
• W2004676972 cites W2329888282 @default.
• W2004676972 doi "https://doi.org/10.3233/dma-120948" @default.
• W2004676972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3809969" @default.
• W2004676972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23324576" @default.
• W2004676972 hasPublicationYear "2013" @default.
• W2004676972 type Work @default.
• W2004676972 sameAs 2004676972 @default.
• W2004676972 citedByCount "28" @default.
• W2004676972 countsByYear W20046769722014 @default.
• W2004676972 countsByYear W20046769722015 @default.
• W2004676972 countsByYear W20046769722016 @default.
• W2004676972 countsByYear W20046769722017 @default.
• W2004676972 countsByYear W20046769722018 @default.
• W2004676972 countsByYear W20046769722019 @default.
• W2004676972 countsByYear W20046769722020 @default.
• W2004676972 countsByYear W20046769722021 @default.
• W2004676972 countsByYear W20046769722022 @default.
• W2004676972 countsByYear W20046769722023 @default.
• W2004676972 crossrefType "journal-article" @default.
• W2004676972 hasAuthorship W2004676972A5025568931 @default.
• W2004676972 hasAuthorship W2004676972A5033251076 @default.
• W2004676972 hasAuthorship W2004676972A5042945020 @default.
• W2004676972 hasAuthorship W2004676972A5048805964 @default.
• W2004676972 hasAuthorship W2004676972A5063085953 @default.
• W2004676972 hasConcept C104317684 @default.
• W2004676972 hasConcept C119056186 @default.
• W2004676972 hasConcept C121608353 @default.
• W2004676972 hasConcept C140173407 @default.
• W2004676972 hasConcept C150194340 @default.
• W2004676972 hasConcept C190727270 @default.
• W2004676972 hasConcept C2781197716 @default.
• W2004676972 hasConcept C33288867 @default.
• W2004676972 hasConcept C41091548 @default.
• W2004676972 hasConcept C502942594 @default.
• W2004676972 hasConcept C526805850 @default.
• W2004676972 hasConcept C54355233 @default.
• W2004676972 hasConcept C71924100 @default.
• W2004676972 hasConcept C86803240 @default.
• W2004676972 hasConceptScore W2004676972C104317684 @default.
• W2004676972 hasConceptScore W2004676972C119056186 @default.
• W2004676972 hasConceptScore W2004676972C121608353 @default.
• W2004676972 hasConceptScore W2004676972C140173407 @default.
• W2004676972 hasConceptScore W2004676972C150194340 @default.
• W2004676972 hasConceptScore W2004676972C190727270 @default.
• W2004676972 hasConceptScore W2004676972C2781197716 @default.
• W2004676972 hasConceptScore W2004676972C33288867 @default.
• W2004676972 hasConceptScore W2004676972C41091548 @default.
• W2004676972 hasConceptScore W2004676972C502942594 @default.
• W2004676972 hasConceptScore W2004676972C526805850 @default.
• W2004676972 hasConceptScore W2004676972C54355233 @default.
• W2004676972 hasConceptScore W2004676972C71924100 @default.
• W2004676972 hasConceptScore W2004676972C86803240 @default.
• W2004676972 hasLocation W20046769721 @default.

• next