FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004677138> ?p ?o ?g. }

• W2004677138 endingPage "611" @default.
• W2004677138 startingPage "604" @default.
• W2004677138 abstract "Antibiotics might, apart from an antimicrobial effect, also exert anti-inflammatory effects. The novel antibiotic tigecycline, potentially useful in septic shock from gram-negative multiresistant bacteria, is structurally related to antibiotics with known anti-inflammatory properties. However, its anti-inflammatory effects have not been previously explored in vivo. Using a sterile integrative porcine sepsis model, we investigated the anti-inflammatory and circulatory effects of tigecycline in comparison with doxycycline and placebo. Eighteen pigs were randomized to receive tigecycline 100 mg, doxycycline 200 mg, or placebo and subjected to 6-h endotoxin infusion at 0.5 μg kg−1 h−1. Markers of inflammation, nitric oxide production, vascular permeability, hemodynamics, organ dysfunction, tissue metabolism, and acid-base parameters were monitored. Peak plasma tumor necrosis factor-α was lower in the doxycycline group (P = 0.031) but not in the tigecycline group (P = 0.86) compared with placebo, with geometric mean plasma concentrations of 16, 79, and 63 ng mL−1, respectively. Mean arterial pressure was higher 4 to 6 h in the tigecycline group, with values at 6 h of 107 ± 9 mmHg compared with the placebo and doxycycline groups (85 ± 27 mmHg and 90 ± 32 mmHg, respectively; P = 0.025). The white blood cell and the neutrophil granulocyte counts were less reduced in the doxycycline group but not in the tigecycline group at 4 to 6 h (P = 0.009 and P = 0.019, respectively). Other markers of inflammation, organ dysfunction, tissue metabolism, and acid-base parameters were unaffected by tigecycline. Consistent with known anti-inflammatory properties, doxycycline yielded decreased tumor necrosis factor-α levels. Tigecycline did not affect cytokine levels but counteracted hypotension and hypoperfusion." @default.
• W2004677138 created "2016-06-24" @default.
• W2004677138 creator A5023485605 @default.
• W2004677138 creator A5042117009 @default.
• W2004677138 creator A5043684931 @default.
• W2004677138 creator A5056305325 @default.
• W2004677138 creator A5062898791 @default.
• W2004677138 creator A5073362815 @default.
• W2004677138 date "2015-06-01" @default.
• W2004677138 modified "2023-10-16" @default.
• W2004677138 title "Effects of Tigecycline and Doxycycline on Inflammation and Hemodynamics in Porcine Endotoxemia" @default.
• W2004677138 cites W1553795208 @default.
• W2004677138 cites W1856680566 @default.
• W2004677138 cites W1969346496 @default.
• W2004677138 cites W1972594523 @default.
• W2004677138 cites W1981265053 @default.
• W2004677138 cites W1984197268 @default.
• W2004677138 cites W1993397663 @default.
• W2004677138 cites W2054675573 @default.
• W2004677138 cites W2054938569 @default.
• W2004677138 cites W2058200273 @default.
• W2004677138 cites W2071677650 @default.
• W2004677138 cites W2127110195 @default.
• W2004677138 cites W2138677862 @default.
• W2004677138 cites W2139509969 @default.
• W2004677138 cites W2148871440 @default.
• W2004677138 cites W2150338463 @default.
• W2004677138 cites W2154007902 @default.
• W2004677138 cites W2328529398 @default.
• W2004677138 cites W2442246762 @default.
• W2004677138 doi "https://doi.org/10.1097/shk.0000000000000351" @default.
• W2004677138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25664982" @default.
• W2004677138 hasPublicationYear "2015" @default.
• W2004677138 type Work @default.
• W2004677138 sameAs 2004677138 @default.
• W2004677138 citedByCount "7" @default.
• W2004677138 countsByYear W20046771382015 @default.
• W2004677138 countsByYear W20046771382017 @default.
• W2004677138 countsByYear W20046771382018 @default.
• W2004677138 countsByYear W20046771382019 @default.
• W2004677138 countsByYear W20046771382020 @default.
• W2004677138 countsByYear W20046771382023 @default.
• W2004677138 crossrefType "journal-article" @default.
• W2004677138 hasAuthorship W2004677138A5023485605 @default.
• W2004677138 hasAuthorship W2004677138A5042117009 @default.
• W2004677138 hasAuthorship W2004677138A5043684931 @default.
• W2004677138 hasAuthorship W2004677138A5056305325 @default.
• W2004677138 hasAuthorship W2004677138A5062898791 @default.
• W2004677138 hasAuthorship W2004677138A5073362815 @default.
• W2004677138 hasConcept C126322002 @default.
• W2004677138 hasConcept C142724271 @default.
• W2004677138 hasConcept C204787440 @default.
• W2004677138 hasConcept C27081682 @default.
• W2004677138 hasConcept C2776914184 @default.
• W2004677138 hasConcept C2777027569 @default.
• W2004677138 hasConcept C2777179404 @default.
• W2004677138 hasConcept C2777628635 @default.
• W2004677138 hasConcept C2778275353 @default.
• W2004677138 hasConcept C2778384902 @default.
• W2004677138 hasConcept C501593827 @default.
• W2004677138 hasConcept C71924100 @default.
• W2004677138 hasConcept C86803240 @default.
• W2004677138 hasConcept C89423630 @default.
• W2004677138 hasConcept C98274493 @default.
• W2004677138 hasConceptScore W2004677138C126322002 @default.
• W2004677138 hasConceptScore W2004677138C142724271 @default.
• W2004677138 hasConceptScore W2004677138C204787440 @default.
• W2004677138 hasConceptScore W2004677138C27081682 @default.
• W2004677138 hasConceptScore W2004677138C2776914184 @default.
• W2004677138 hasConceptScore W2004677138C2777027569 @default.
• W2004677138 hasConceptScore W2004677138C2777179404 @default.
• W2004677138 hasConceptScore W2004677138C2777628635 @default.
• W2004677138 hasConceptScore W2004677138C2778275353 @default.
• W2004677138 hasConceptScore W2004677138C2778384902 @default.
• W2004677138 hasConceptScore W2004677138C501593827 @default.
• W2004677138 hasConceptScore W2004677138C71924100 @default.
• W2004677138 hasConceptScore W2004677138C86803240 @default.
• W2004677138 hasConceptScore W2004677138C89423630 @default.
• W2004677138 hasConceptScore W2004677138C98274493 @default.
• W2004677138 hasIssue "6" @default.
• W2004677138 hasLocation W20046771381 @default.
• W2004677138 hasLocation W20046771382 @default.
• W2004677138 hasOpenAccess W2004677138 @default.
• W2004677138 hasPrimaryLocation W20046771381 @default.
• W2004677138 hasRelatedWork W2022573780 @default.
• W2004677138 hasRelatedWork W2120576108 @default.
• W2004677138 hasRelatedWork W2165886321 @default.
• W2004677138 hasRelatedWork W2363528596 @default.
• W2004677138 hasRelatedWork W2406356995 @default.
• W2004677138 hasRelatedWork W2466684896 @default.
• W2004677138 hasRelatedWork W2612294841 @default.
• W2004677138 hasRelatedWork W4244601012 @default.
• W2004677138 hasRelatedWork W4246729077 @default.
• W2004677138 hasRelatedWork W4385497594 @default.
• W2004677138 hasVolume "43" @default.
• W2004677138 isParatext "false" @default.
• W2004677138 isRetracted "false" @default.
• W2004677138 magId "2004677138" @default.

• next