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- W2004678448 abstract "We recently described a monocyte pro-inflammatory state in patients with bipolar disorder (BD). We hypothesized that the CD4+T cell system is also activated and determined percentages of Th1, Th2, Th17 and CD4+CD25highFoxP3+ regulatory T cells.We carried out a detailed FACS analysis to determine the various T cell subsets and used frozen stored peripheral blood mononuclear cells (PBMC) of 38 BD patients (of whom we previously had tested monocytes for pro-inflammatory gene expression (Drexhage et al., 2010a, Padmos et al., 2008)) and of 22 age/gender matched healthy controls (HC). In addition the cytokines CCL2, IL-1β, IL-6, TNF-α, PTX3, IL-10, IFN-γ, IL-17A, IL-4, IL-5 and IL-22 were measured in serum.(a) Serum sCD25 levels and percentages of anti-inflammatory CD4+CD25highFoxP3+ regulatory T cells were higher, the latter in BD patients <40 years of age. Percentages of Th1, Th2 and Th17 cells were normal.(b) Of the pro-inflammatory monocyte cytokines CCL2 and PTX3 were raised in serum.(c) The monocyte pro-inflammatory state and the raised percentages of CD4+CD25highFoxP3+ regulatory T cells occurred independently from each other.(d) In BD patients positive for thyroid autoimmune disease a significantly reduced percentage of CD4+CD25highFoxP3+ regulatory T cells was found as compared to BD patients without AITD.Our data show an enhancement of pro-inflammatory monocyte and anti-inflammatory T cell forces in BD patients. A lack of anti-inflammatory T cell forces co-occurred with AITD in BD patients." @default.
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- W2004678448 date "2010-08-01" @default.
- W2004678448 modified "2023-09-24" @default.
- W2004678448 title "P.2.f.001 Lithium treatment is not associated with functional or autoimmunitarian thyroideal abnormalities in bipolar disorder I" @default.
- W2004678448 doi "https://doi.org/10.1016/s0924-977x(10)70601-5" @default.
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