FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004679580> ?p ?o ?g. }

• W2004679580 abstract "1. A thrombus was induced in the rat femoral artery by endothelial damage due to the photochemical reaction between systemically-injected Rose Bengal and transillumination with green light (wavelength: 540 nm). The artery of the control rat was completely occluded in 302.8 +/- 27.0 s after the initiation of the reaction. 2. Pretreatment with vapiprost (0.1, 0.3 and 1.0 mg kg-1, i.v., 5 min before the reaction) prolonged the time required to occlude the femoral artery in a dose-dependent manner. The efficacy of vapiprost on the time required for occlusion was over 10 times higher than that of aspirin which was administered 30 min before the reaction. 3. The thrombolytic effects of tissue-type plasminogen activator (tPA) on the established arterial thrombus in the presence and absence of vapiprost were also studied in the same model. When vapiprost (0.3 mg kg-1, i.v.) was administered just before tPA infusion (100 micrograms kg-1 min-1 for 30 min), the time required to reperfuse the occluded artery was reduced, the incidence of the reperfusion was increased and the arterial blood flow after reperfusion was improved. 4. When vapiprost (1.0 mg kg-1 daily p.o.) was administered for 1 week after the establishment of reperfusion by tPA combined with vapiprost, the patency of the reperfused artery was improved and the femoral arterial blood flow was better preserved than after treatment with only tPA. 5. These findings suggest that this thromboxane receptor antagonist may be a useful adjunct to anti-thrombotic therapy. The combination therapy with tPA may be more effective than treatment with tPA alone and provides greater protection against reocclusion after reperfusion." @default.
• W2004679580 created "2016-06-24" @default.
• W2004679580 creator A5007554872 @default.
• W2004679580 creator A5012000909 @default.
• W2004679580 creator A5051905802 @default.
• W2004679580 creator A5055679307 @default.
• W2004679580 creator A5064440844 @default.
• W2004679580 creator A5088804804 @default.
• W2004679580 date "1992-07-01" @default.
• W2004679580 modified "2023-10-16" @default.
• W2004679580 title "Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator" @default.
• W2004679580 cites W159927799 @default.
• W2004679580 cites W167748911 @default.
• W2004679580 cites W1912161359 @default.
• W2004679580 cites W1974882457 @default.
• W2004679580 cites W1986940955 @default.
• W2004679580 cites W2001729311 @default.
• W2004679580 cites W2009005487 @default.
• W2004679580 cites W2012241915 @default.
• W2004679580 cites W2016051580 @default.
• W2004679580 cites W2040041623 @default.
• W2004679580 cites W2041135180 @default.
• W2004679580 cites W2068165000 @default.
• W2004679580 cites W2085096528 @default.
• W2004679580 cites W2102395898 @default.
• W2004679580 cites W2131164001 @default.
• W2004679580 cites W2145318640 @default.
• W2004679580 cites W2146083057 @default.
• W2004679580 cites W2151875550 @default.
• W2004679580 cites W2169838114 @default.
• W2004679580 cites W2272087247 @default.
• W2004679580 cites W2408523140 @default.
• W2004679580 cites W2411793165 @default.
• W2004679580 cites W2416041433 @default.
• W2004679580 cites W2434699632 @default.
• W2004679580 cites W4252908880 @default.
• W2004679580 doi "https://doi.org/10.1111/j.1476-5381.1992.tb14370.x" @default.
• W2004679580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1907568" @default.
• W2004679580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1387025" @default.
• W2004679580 hasPublicationYear "1992" @default.
• W2004679580 type Work @default.
• W2004679580 sameAs 2004679580 @default.
• W2004679580 citedByCount "27" @default.
• W2004679580 countsByYear W20046795802014 @default.
• W2004679580 countsByYear W20046795802016 @default.
• W2004679580 crossrefType "journal-article" @default.
• W2004679580 hasAuthorship W2004679580A5007554872 @default.
• W2004679580 hasAuthorship W2004679580A5012000909 @default.
• W2004679580 hasAuthorship W2004679580A5051905802 @default.
• W2004679580 hasAuthorship W2004679580A5055679307 @default.
• W2004679580 hasAuthorship W2004679580A5064440844 @default.
• W2004679580 hasAuthorship W2004679580A5088804804 @default.
• W2004679580 hasBestOaLocation W20046795802 @default.
• W2004679580 hasConcept C126322002 @default.
• W2004679580 hasConcept C158846371 @default.
• W2004679580 hasConcept C2776572282 @default.
• W2004679580 hasConcept C2776785769 @default.
• W2004679580 hasConcept C2776820930 @default.
• W2004679580 hasConcept C2777628954 @default.
• W2004679580 hasConcept C2779581417 @default.
• W2004679580 hasConcept C2779679481 @default.
• W2004679580 hasConcept C2779723990 @default.
• W2004679580 hasConcept C2781362458 @default.
• W2004679580 hasConcept C2909373784 @default.
• W2004679580 hasConcept C2909817843 @default.
• W2004679580 hasConcept C42219234 @default.
• W2004679580 hasConcept C500558357 @default.
• W2004679580 hasConcept C71924100 @default.
• W2004679580 hasConcept C89560881 @default.
• W2004679580 hasConcept C98274493 @default.
• W2004679580 hasConceptScore W2004679580C126322002 @default.
• W2004679580 hasConceptScore W2004679580C158846371 @default.
• W2004679580 hasConceptScore W2004679580C2776572282 @default.
• W2004679580 hasConceptScore W2004679580C2776785769 @default.
• W2004679580 hasConceptScore W2004679580C2776820930 @default.
• W2004679580 hasConceptScore W2004679580C2777628954 @default.
• W2004679580 hasConceptScore W2004679580C2779581417 @default.
• W2004679580 hasConceptScore W2004679580C2779679481 @default.
• W2004679580 hasConceptScore W2004679580C2779723990 @default.
• W2004679580 hasConceptScore W2004679580C2781362458 @default.
• W2004679580 hasConceptScore W2004679580C2909373784 @default.
• W2004679580 hasConceptScore W2004679580C2909817843 @default.
• W2004679580 hasConceptScore W2004679580C42219234 @default.
• W2004679580 hasConceptScore W2004679580C500558357 @default.
• W2004679580 hasConceptScore W2004679580C71924100 @default.
• W2004679580 hasConceptScore W2004679580C89560881 @default.
• W2004679580 hasConceptScore W2004679580C98274493 @default.
• W2004679580 hasLocation W20046795801 @default.
• W2004679580 hasLocation W20046795802 @default.
• W2004679580 hasLocation W20046795803 @default.
• W2004679580 hasLocation W20046795804 @default.
• W2004679580 hasOpenAccess W2004679580 @default.
• W2004679580 hasPrimaryLocation W20046795801 @default.
• W2004679580 hasRelatedWork W1973744645 @default.
• W2004679580 hasRelatedWork W2003323425 @default.
• W2004679580 hasRelatedWork W2004679580 @default.
• W2004679580 hasRelatedWork W2008047831 @default.
• W2004679580 hasRelatedWork W2011225438 @default.
• W2004679580 hasRelatedWork W2042475987 @default.
• W2004679580 hasRelatedWork W2072944021 @default.

• next