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• W2004682603 abstract "Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone consisting of an α and a β subunit that stimulates intracellular levels of cAMP via a G protein-coupled receptor. Herein we report the engineering and characterization of a novel molecule in which the receptor and its heterodimeric ligand were covalently linked in a single polypeptide chain. The hormone-receptor complex was expressed in cells transfected with this construct, but the cells were unable to bind significant amounts of exogenous hCG. However, cleavage of the hormone with a site-specific protease rendered the receptor accessible to exogenously added hormone. Cells transfected with the hCG-receptor construct contained elevated basal levels of cAMP; moreover, addition of hormone had no significant effect. These results are consistent with a strong and stable interaction between the single-chain hormone and its covalently linked receptor that results in a constitutively active complex." @default.
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• W2004682603 date "1996-12-01" @default.
• W2004682603 modified "2023-09-28" @default.
• W2004682603 title "Protein Engineering of a Novel Constitutively Active Hormone-Receptor Complex" @default.
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• W2004682603 doi "https://doi.org/10.1074/jbc.271.49.31638" @default.
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