Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004685936> ?p ?o ?g. }
- W2004685936 endingPage "370" @default.
- W2004685936 startingPage "362" @default.
- W2004685936 abstract "The antioxidant and antiglucotoxic effects of Alternanthera paronychioides on pancreatic β-cell were investigated. Antioxidant assays demonstrated that ethanol extracts of A. paronychioides (EEAP) exhibited the highest antioxidant activity, which also had the highest phenolic and flavonoid contents. Two major polyphenolics, ferulic acid and quercetin, were identified from EEAP by HPLC-DAD. Effects of EEAP, ferulic acid and quercetin on high glucose (25 mmol/L)-induced pancreatic β-cell apoptosis and dysfunction were further evaluated. Results showed that EEAP and quercetin but not ferulic acid protected β-cells from glucotoxicity through several mechanisms, including: (1) maintaining β-cell viability; (2) suppressing reactive oxygen species production; (3) reducing characteristic features of apoptosis; (4) inhibiting the activation of caspase-9 and caspase-3 and the cleavage of poly (ADP-ribose) polymerase; (5) upregulating pancreatic and duodenal homeobox 1 gene expression and the insulin secretagogue action of pancreatic β-cells. These findings may shed light on the preventive actions of A. paronychioides on diabetic glucotoxicity." @default.
- W2004685936 created "2016-06-24" @default.
- W2004685936 creator A5016811323 @default.
- W2004685936 creator A5022131769 @default.
- W2004685936 creator A5029670240 @default.
- W2004685936 creator A5067811834 @default.
- W2004685936 date "2013-08-01" @default.
- W2004685936 modified "2023-09-26" @default.
- W2004685936 title "Alternanthera paronychioides protects pancreatic β-cells from glucotoxicity by its antioxidant, antiapoptotic and insulin secretagogue actions" @default.
- W2004685936 cites W1745634660 @default.
- W2004685936 cites W1921050281 @default.
- W2004685936 cites W1964617786 @default.
- W2004685936 cites W1974387714 @default.
- W2004685936 cites W1979636493 @default.
- W2004685936 cites W1982650705 @default.
- W2004685936 cites W1987686493 @default.
- W2004685936 cites W2000118672 @default.
- W2004685936 cites W2002895460 @default.
- W2004685936 cites W2006257317 @default.
- W2004685936 cites W2017593938 @default.
- W2004685936 cites W2021550936 @default.
- W2004685936 cites W2037284265 @default.
- W2004685936 cites W2044321657 @default.
- W2004685936 cites W2053470738 @default.
- W2004685936 cites W2056778474 @default.
- W2004685936 cites W2057692152 @default.
- W2004685936 cites W2060431825 @default.
- W2004685936 cites W2072628959 @default.
- W2004685936 cites W2074152898 @default.
- W2004685936 cites W2077737366 @default.
- W2004685936 cites W2080546358 @default.
- W2004685936 cites W2082260895 @default.
- W2004685936 cites W2111501638 @default.
- W2004685936 cites W2116313215 @default.
- W2004685936 cites W2126700142 @default.
- W2004685936 cites W2145595413 @default.
- W2004685936 cites W2154868232 @default.
- W2004685936 doi "https://doi.org/10.1016/j.foodchem.2013.01.026" @default.
- W2004685936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23561118" @default.
- W2004685936 hasPublicationYear "2013" @default.
- W2004685936 type Work @default.
- W2004685936 sameAs 2004685936 @default.
- W2004685936 citedByCount "18" @default.
- W2004685936 countsByYear W20046859362014 @default.
- W2004685936 countsByYear W20046859362016 @default.
- W2004685936 countsByYear W20046859362017 @default.
- W2004685936 countsByYear W20046859362018 @default.
- W2004685936 countsByYear W20046859362021 @default.
- W2004685936 countsByYear W20046859362022 @default.
- W2004685936 crossrefType "journal-article" @default.
- W2004685936 hasAuthorship W2004685936A5016811323 @default.
- W2004685936 hasAuthorship W2004685936A5022131769 @default.
- W2004685936 hasAuthorship W2004685936A5029670240 @default.
- W2004685936 hasAuthorship W2004685936A5067811834 @default.
- W2004685936 hasConcept C185592680 @default.
- W2004685936 hasConcept C190283241 @default.
- W2004685936 hasConcept C2776151105 @default.
- W2004685936 hasConcept C2778004101 @default.
- W2004685936 hasConcept C2780161494 @default.
- W2004685936 hasConcept C2780213334 @default.
- W2004685936 hasConcept C2781263971 @default.
- W2004685936 hasConcept C48349386 @default.
- W2004685936 hasConcept C49039625 @default.
- W2004685936 hasConcept C53227056 @default.
- W2004685936 hasConcept C55493867 @default.
- W2004685936 hasConcept C86803240 @default.
- W2004685936 hasConcept C98274493 @default.
- W2004685936 hasConceptScore W2004685936C185592680 @default.
- W2004685936 hasConceptScore W2004685936C190283241 @default.
- W2004685936 hasConceptScore W2004685936C2776151105 @default.
- W2004685936 hasConceptScore W2004685936C2778004101 @default.
- W2004685936 hasConceptScore W2004685936C2780161494 @default.
- W2004685936 hasConceptScore W2004685936C2780213334 @default.
- W2004685936 hasConceptScore W2004685936C2781263971 @default.
- W2004685936 hasConceptScore W2004685936C48349386 @default.
- W2004685936 hasConceptScore W2004685936C49039625 @default.
- W2004685936 hasConceptScore W2004685936C53227056 @default.
- W2004685936 hasConceptScore W2004685936C55493867 @default.
- W2004685936 hasConceptScore W2004685936C86803240 @default.
- W2004685936 hasConceptScore W2004685936C98274493 @default.
- W2004685936 hasFunder F4320311687 @default.
- W2004685936 hasFunder F4320321040 @default.
- W2004685936 hasFunder F4320328149 @default.
- W2004685936 hasIssue "1-4" @default.
- W2004685936 hasLocation W20046859361 @default.
- W2004685936 hasLocation W20046859362 @default.
- W2004685936 hasOpenAccess W2004685936 @default.
- W2004685936 hasPrimaryLocation W20046859361 @default.
- W2004685936 hasRelatedWork W1490540217 @default.
- W2004685936 hasRelatedWork W1979028833 @default.
- W2004685936 hasRelatedWork W2184915799 @default.
- W2004685936 hasRelatedWork W2313463101 @default.
- W2004685936 hasRelatedWork W2347577273 @default.
- W2004685936 hasRelatedWork W2368772701 @default.
- W2004685936 hasRelatedWork W2395941482 @default.
- W2004685936 hasRelatedWork W2791181644 @default.
- W2004685936 hasRelatedWork W3197540311 @default.
- W2004685936 hasRelatedWork W99063305 @default.