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• W2004688384 abstract "Interleukin-6 (IL-6) and ciliary neurotrophic factor (CNTF) share a signal-transducing molecule called gp130. Previous studies showed that CNTF regulates fibrinogen gene expression in rat hepatocytes by competitive binding to the IL-6 receptor. This report explores the post ligand-binding events in the control of fibrinogen and early response gene production stimulated by IL-6 and CNTF in primary rat hepatocytes. Metabolic labeling, using [32P]orthophosphate or anti-phosphotyrosine antibody (Ab) blot experiments revealed that both IL-6 and CNTF induced tyrosine phosphorylation of gp130, and the Jak1 and Jak2 kinases in a dose- and time-dependent manner. Additional experiments revealed that only one of the early response genes, junb, but not c-myc or c-fos, was stimulated by the addition of either IL-6 or CNTF. These data suggest that activation of Jak kinases and stimulation of junb reflect a divergence of the IL-6/CNTF signaling pathway and further suggest that junb may participate in cytokine control of acute-phase protein production in the inflammatory response." @default.
• W2004688384 created "2016-06-24" @default.
• W2004688384 creator A5003642180 @default.
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• W2004688384 date "1995-09-01" @default.
• W2004688384 modified "2023-10-17" @default.
• W2004688384 title "Interleukin-6 and ciliary neurotrophic factor trigger Janus kinase activation and early gene response in rat hepatocytes" @default.
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• W2004688384 doi "https://doi.org/10.1016/0378-1119(95)00295-h" @default.
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