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• W2004688701 abstract "Opioid antagonism and serotonergic stimulation is associated with macronutrient-specific hypophagia in animals. In the present study we evaluated their systemic effect alone, and in combination, at various doses, on the intake of sweet carbohydrate-rich and sweet fat-rich foods, tastes, and nutrients that are typical of binge-food items. Low-dose (1 mg/kg) naloxone, alone, preferentially suppressed fat-rich intake while low-dose (2.5 mg/kg) fluoxetine, alone, preferentially suppressed carbohydrate-rich intake. Each drug at these doses, combined with various doses of the other (2.5-10 mg/kg fluoxetine; 0.01-1 mg/kg naloxone) additively suppressed both kinds of the sweet foods. Naloxone and fluoxetine have therapeutic potential in treating binge-eating disorders. This animal study suggests what shortcomings and benefits might be expected when combining these two agents." @default.
• W2004688701 created "2016-06-24" @default.
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• W2004688701 date "1997-12-01" @default.
• W2004688701 modified "2023-10-16" @default.
• W2004688701 title "Combined Naloxone and Fluoxetine on Deprivation-Induced Binge Eating of Palatable Foods in Rats" @default.
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• W2004688701 doi "https://doi.org/10.1016/s0091-3057(97)00318-3" @default.
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