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- W2004694897 abstract "Abstract Diffusion‐weighted imaging (DWI) has become one of the most important imaging modalities for the characterization of acute stroke. In this review article the connection between DWI and independent non‐MR parameters is evaluated, thereby providing the background for the physiological and metabolic interpretation of DWI changes. The pathophysiological consequences reflected by DWI changes are determined by the duration and intensity of an ischemic event. Reversible changes in water diffusion of tissue are triggered at a cerebral blood flow decrease to approximately 35–40 mL/100g*min. More severe hemodynamic disturbances (<20 mL/100g*min) obviously result in irreversible tissue damage. Furthermore, a distinct relative decrease of the apparent diffusion coefficient (ADC) to 90% of control indicates tissue acidosis, and it has been shown that, under certain conditions, the ADC reflects the current energy state of the brain, as validated by the distribution of ATP. A close correlation between the depletion of ATP and an ADC decrease to 77% of control was found for the acute phase of both permanent and transient cerebral ischemia. The correlation of diffusion changes with final tissue damage revealed that ADC can reliably predict histopathological damage during the early acute phase of cerebral ischemia and after transient recovery. However, in the intermediate phase, while histology showed further cellular degeneration, ADC obviously does not reflect the tissue status. Depending on the individual situation, a moderate ADC decrease to ca. 70–80% of control must not necessarily result in irreversible tissue damage, whereas more severe decline to ca. 60% of control presumably transforms to necrosis." @default.
- W2004694897 created "2016-06-24" @default.
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- W2004694897 date "2003-11-01" @default.
- W2004694897 modified "2023-09-27" @default.
- W2004694897 title "Physiological and Metabolic Interpretation of Diffusion-Weighted Imaging Changes During Cerebral Ischemia" @default.
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- W2004694897 doi "https://doi.org/10.1560/0bcg-d9vn-kgm9-hkfc" @default.
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