FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004696592> ?p ?o ?g. }

• W2004696592 endingPage "2563" @default.
• W2004696592 startingPage "2549" @default.
• W2004696592 abstract "A stylized, symmetric, compartmental model of a dopamine neuron in vivo shows how rate and pattern can be modulated either concurrently or differentially. If two or more parameters in the model are varied concurrently, the baseline firing rate and the extent of bursting become de-correlated, which provides an explanation for the lack of a tight correlation in vivo and is consistent with some independence of the mechanisms that generate baseline firing rates versus bursts. We hypothesize that most bursts are triggered by a barrage of synaptic input and that particularly meaningful stimuli recruit larger numbers of synapses in a more synchronous way. An example of concurrent modulation is that increasing the short-lived AMPA current evokes additional spikes without regard to pattern, producing comparable increases in spike frequency and fraction fired in bursts. On the other hand, blocking the SK current evokes additional bursts by allowing a depolarization that previously produced only a single spike to elicit two or more and elongates existing bursts by the same principle, resulting in a greater effect on pattern than rate. A probabilistic algorithm for the random insertion of spikes into the firing pattern produces a good approximation to the pattern changes induced by increasing the AMPA conductance, but not by blocking the SK current, consistent with a differential modulation in the latter case. Furthermore, blocking SK produced a longer burst with a greater intra-burst frequency in response to a simulated meaningful input, suggesting that reduction of this current may augment reward-related responses." @default.
• W2004696592 created "2016-06-24" @default.
• W2004696592 creator A5056283225 @default.
• W2004696592 creator A5088931698 @default.
• W2004696592 date "2006-11-01" @default.
• W2004696592 modified "2023-09-24" @default.
• W2004696592 title "An Increase in AMPA and a Decrease in SK Conductance Increase Burst Firing by Different Mechanisms in a Model of a Dopamine Neuron In Vivo" @default.
• W2004696592 cites W1509225761 @default.
• W2004696592 cites W1533673027 @default.
• W2004696592 cites W1567696719 @default.
• W2004696592 cites W1598372418 @default.
• W2004696592 cites W1633847368 @default.
• W2004696592 cites W1644438397 @default.
• W2004696592 cites W1646563530 @default.
• W2004696592 cites W1949404224 @default.
• W2004696592 cites W1970249278 @default.
• W2004696592 cites W1976749972 @default.
• W2004696592 cites W1980261438 @default.
• W2004696592 cites W1989123260 @default.
• W2004696592 cites W1989176150 @default.
• W2004696592 cites W1992894736 @default.
• W2004696592 cites W1993369233 @default.
• W2004696592 cites W1995362640 @default.
• W2004696592 cites W2007004601 @default.
• W2004696592 cites W2009809272 @default.
• W2004696592 cites W2010192358 @default.
• W2004696592 cites W2010408075 @default.
• W2004696592 cites W2011434472 @default.
• W2004696592 cites W2014796143 @default.
• W2004696592 cites W2016364765 @default.
• W2004696592 cites W2019402390 @default.
• W2004696592 cites W2020455022 @default.
• W2004696592 cites W2022917563 @default.
• W2004696592 cites W2041583292 @default.
• W2004696592 cites W2043505035 @default.
• W2004696592 cites W2050136925 @default.
• W2004696592 cites W2052676993 @default.
• W2004696592 cites W2060040098 @default.
• W2004696592 cites W2073706581 @default.
• W2004696592 cites W2075831689 @default.
• W2004696592 cites W2090020119 @default.
• W2004696592 cites W2095427325 @default.
• W2004696592 cites W2095897702 @default.
• W2004696592 cites W2100068597 @default.
• W2004696592 cites W2109059823 @default.
• W2004696592 cites W2135810087 @default.
• W2004696592 cites W2152648188 @default.
• W2004696592 cites W2156520482 @default.
• W2004696592 cites W2158978788 @default.
• W2004696592 cites W2169154493 @default.
• W2004696592 cites W2210277409 @default.
• W2004696592 cites W2264979256 @default.
• W2004696592 cites W2270800518 @default.
• W2004696592 cites W2404614583 @default.
• W2004696592 cites W2413295084 @default.
• W2004696592 doi "https://doi.org/10.1152/jn.00704.2006" @default.
• W2004696592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2531289" @default.
• W2004696592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16885519" @default.
• W2004696592 hasPublicationYear "2006" @default.
• W2004696592 type Work @default.
• W2004696592 sameAs 2004696592 @default.
• W2004696592 citedByCount "70" @default.
• W2004696592 countsByYear W20046965922012 @default.
• W2004696592 countsByYear W20046965922013 @default.
• W2004696592 countsByYear W20046965922014 @default.
• W2004696592 countsByYear W20046965922015 @default.
• W2004696592 countsByYear W20046965922016 @default.
• W2004696592 countsByYear W20046965922017 @default.
• W2004696592 countsByYear W20046965922018 @default.
• W2004696592 countsByYear W20046965922019 @default.
• W2004696592 countsByYear W20046965922020 @default.
• W2004696592 countsByYear W20046965922021 @default.
• W2004696592 countsByYear W20046965922022 @default.
• W2004696592 countsByYear W20046965922023 @default.
• W2004696592 crossrefType "journal-article" @default.
• W2004696592 hasAuthorship W2004696592A5056283225 @default.
• W2004696592 hasAuthorship W2004696592A5088931698 @default.
• W2004696592 hasBestOaLocation W20046965922 @default.
• W2004696592 hasConcept C121332964 @default.
• W2004696592 hasConcept C121932024 @default.
• W2004696592 hasConcept C12554922 @default.
• W2004696592 hasConcept C160268369 @default.
• W2004696592 hasConcept C169760540 @default.
• W2004696592 hasConcept C170493617 @default.
• W2004696592 hasConcept C185592680 @default.
• W2004696592 hasConcept C195221683 @default.
• W2004696592 hasConcept C26873012 @default.
• W2004696592 hasConcept C4141045 @default.
• W2004696592 hasConcept C55493867 @default.
• W2004696592 hasConcept C67018056 @default.
• W2004696592 hasConcept C86803240 @default.
• W2004696592 hasConceptScore W2004696592C121332964 @default.
• W2004696592 hasConceptScore W2004696592C121932024 @default.
• W2004696592 hasConceptScore W2004696592C12554922 @default.
• W2004696592 hasConceptScore W2004696592C160268369 @default.
• W2004696592 hasConceptScore W2004696592C169760540 @default.
• W2004696592 hasConceptScore W2004696592C170493617 @default.
• W2004696592 hasConceptScore W2004696592C185592680 @default.

• next