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- W2004702241 abstract "In vivo experiments in mice demonstrated that 5% CO2 content in the air inhaled did not change the labelling in autoradiograms from animals injected with [3H]uridine, [3H]orotic acid, [3H]hypoxanthine, [3H]lysine or [3H]cytidine. At 20% CO2 content there was a significant decrease in labelling of brain cells with [3H]uridine and [3H]cytidine, but not following [3H]lysine; there was no labelling of nerve cells with [3H]orotic acid or [3H]hypoxanthine, but a control group was not included. The labelling of choroid plexus and hepatocytes was independent of the CO2 concentration. A comparison of in vivo and in vitro experiments at 20% CO2 content showed a similar significant decrease in labelling of brain cells with [3H]uridine and [3H]cytidine. It is concluded that a metabolic change is the most appropriate explanation of the CO2 effect." @default.
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- W2004702241 title "CO2 anaesthesia inhibits RNA synthesis" @default.
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- W2004702241 doi "https://doi.org/10.1016/0006-8993(70)90426-9" @default.
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