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- W2004702471 abstract "Neurofibrillary changes are a core histochemical neuropathology in Alzheimer's disease (AD), and the concentration of phosphorylated tau (p-tau) and total tau in the cerebrospinal fluid (CSF) as in vivo biological markers of neurofibrillary pathology are increased in patients AD and mild cognitive impairment (MCI). However, it is less well known whether neurofibrillary changes are related to risk factors of AD. Here we assess the association of metabolic (body weight) and genetic risk factors in relation to changes in CSF-tau and p-tau181 in AD and MCI. Changes in body mass index (BMI) are known to be related to core Abeta and neurofibrillary pathology in the brain as assessed in post-mortem studies so far. In order to examine whether BMI is related to CSF-levels of tau, we examined in a total of 56 patients diagnosed with probable AD according to the NINCDS-ADRDA criteria and 43 healthy controls (HC) the CSF-concentration of total tau, p-tau181, and beta amyloid (Aβ1-42). In a larger sample of AD and amnestic MCI subjects, the association between primary genetic risk factors including polymorphisms such as CALHM1, SORLA, and (ApoE) genotype were assessed in relation to differences in the concentration of the CSF-concentration of tau and p-tau181. A decrease in BMI was associated with increased CSF-levels of p-tau181 (p = 0.01), controlled for age, gender, MMSE, years of education, and ApoE genotype. Similarly, higher CSF-concentration of total tau were associated with a decrease in BMI (p = 0.001). The concentration of Aβ1-42 in CSF was not related to BMI (p > 0.05). The direct association between genetic polymorphisms including ApoE genotype, CALHM1, SORLA and the CSF-concentration of p-tau181 and tau in subjects with AD and MCI will be discussed. Lower BMI is indicative of higher CSF-concentration of p-tau181 and total tau in AD, consistent with post-mortem findings. Future studies need to investigate whether such changes in BMI are related to a larger metabolic syndrome including inflammation and glucose metabolism in AD. The determination of CSF-concentration of p-tau provides an in vivo measure to assess whether increased genetic risk of AD is associated with neurofibrillary pathology." @default.
- W2004702471 created "2016-06-24" @default.
- W2004702471 creator A5042997188 @default.
- W2004702471 date "2009-07-01" @default.
- W2004702471 modified "2023-09-27" @default.
- W2004702471 title "S2-01-04: Association between CSF phosphorylated tau and risk factors of Alzheimer's disease" @default.
- W2004702471 doi "https://doi.org/10.1016/j.jalz.2009.05.248" @default.
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