FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004704734> ?p ?o ?g. }

• W2004704734 endingPage "e28551" @default.
• W2004704734 startingPage "e28551" @default.
• W2004704734 abstract "HCV infection is a major cause of chronic liver disease and liver cancer in the United States. To address the pathogenesis caused by HCV infection, recent studies have focused on the direct cytopathic effects of individual HCV proteins, with the objective of identifying their specific roles in the overall pathogenesis. However, this approach precludes examination of the possible interactions between different HCV proteins and organelles. To obtain a better understanding of the various cytopathic effects of and cellular responses to HCV proteins, we used human hepatoma cells constitutively replicating HCV RNA encoding either the full-length polyprotein or the non-structural proteins, or cells constitutively expressing the structural protein core, to model the state of persistent HCV infection and examined the combination of various HCV proteins in cellular pathogenesis. Increased reactive oxygen species (ROS) generation in the mitochondria, mitochondrial injury and degeneration, and increased lipid accumulation were common among all HCV protein-expressing cells regardless of whether they expressed the structural or non-structural proteins. Expression of the non-structural proteins also led to increased oxidative stress in the cytosol, membrane blebbing in the endoplasmic reticulum, and accumulation of autophagocytic vacuoles. Alterations of cellular redox state, on the other hand, significantly changed the level of autophagy, suggesting a direct link between oxidative stress and HCV-mediated activation of autophagy. With the wide-spread cytopathic effects, cells with the full-length HCV polyprotein showed a modest antioxidant response and exhibited a significant increase in population doubling time and a concomitant decrease in cyclin D1. In contrast, cells expressing the non-structural proteins were able to launch a vigorous antioxidant response with up-regulation of antioxidant enzymes. The population doubling time and cyclin D1 level were also comparable to that of control cells. Finally, the cytopathic effects of core protein appeared to focus on the mitochondria without remarkable disturbances in the cytosol." @default.
• W2004704734 created "2016-06-24" @default.
• W2004704734 creator A5000919272 @default.
• W2004704734 creator A5007020491 @default.
• W2004704734 creator A5007869873 @default.
• W2004704734 creator A5008972554 @default.
• W2004704734 creator A5039155716 @default.
• W2004704734 creator A5055386038 @default.
• W2004704734 creator A5057107186 @default.
• W2004704734 creator A5070415173 @default.
• W2004704734 creator A5077425218 @default.
• W2004704734 date "2011-12-02" @default.
• W2004704734 modified "2023-10-13" @default.
• W2004704734 title "Persistent Expression of Hepatitis C Virus Non-Structural Proteins Leads to Increased Autophagy and Mitochondrial Injury in Human Hepatoma Cells" @default.
• W2004704734 cites W1838530486 @default.
• W2004704734 cites W1928472258 @default.
• W2004704734 cites W1943372705 @default.
• W2004704734 cites W1967820787 @default.
• W2004704734 cites W1969339170 @default.
• W2004704734 cites W1970486929 @default.
• W2004704734 cites W1974136748 @default.
• W2004704734 cites W1979139937 @default.
• W2004704734 cites W1982990246 @default.
• W2004704734 cites W1985680307 @default.
• W2004704734 cites W1988796772 @default.
• W2004704734 cites W1991105254 @default.
• W2004704734 cites W1999928435 @default.
• W2004704734 cites W2002123263 @default.
• W2004704734 cites W2003682019 @default.
• W2004704734 cites W2008818215 @default.
• W2004704734 cites W2009228935 @default.
• W2004704734 cites W2013000450 @default.
• W2004704734 cites W2020250268 @default.
• W2004704734 cites W2021199098 @default.
• W2004704734 cites W2028692573 @default.
• W2004704734 cites W2029834382 @default.
• W2004704734 cites W2031042243 @default.
• W2004704734 cites W2032094407 @default.
• W2004704734 cites W2033651440 @default.
• W2004704734 cites W2042637324 @default.
• W2004704734 cites W2048163544 @default.
• W2004704734 cites W2050430849 @default.
• W2004704734 cites W2052350122 @default.
• W2004704734 cites W2053009244 @default.
• W2004704734 cites W2053076589 @default.
• W2004704734 cites W2054902965 @default.
• W2004704734 cites W2056442706 @default.
• W2004704734 cites W2060151133 @default.
• W2004704734 cites W2062216905 @default.
• W2004704734 cites W2063323349 @default.
• W2004704734 cites W2079046408 @default.
• W2004704734 cites W2079289661 @default.
• W2004704734 cites W2082933842 @default.
• W2004704734 cites W2086127478 @default.
• W2004704734 cites W2087209616 @default.
• W2004704734 cites W2087842843 @default.
• W2004704734 cites W2090825777 @default.
• W2004704734 cites W2097176143 @default.
• W2004704734 cites W2101348459 @default.
• W2004704734 cites W2104140554 @default.
• W2004704734 cites W2111899042 @default.
• W2004704734 cites W2116033657 @default.
• W2004704734 cites W2119371081 @default.
• W2004704734 cites W2127481048 @default.
• W2004704734 cites W2129065418 @default.
• W2004704734 cites W2129505300 @default.
• W2004704734 cites W2135612279 @default.
• W2004704734 cites W2139172730 @default.
• W2004704734 cites W2145783052 @default.
• W2004704734 cites W2155431764 @default.
• W2004704734 cites W2170996825 @default.
• W2004704734 doi "https://doi.org/10.1371/journal.pone.0028551" @default.
• W2004704734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3229600" @default.
• W2004704734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22164304" @default.
• W2004704734 hasPublicationYear "2011" @default.
• W2004704734 type Work @default.
• W2004704734 sameAs 2004704734 @default.
• W2004704734 citedByCount "47" @default.
• W2004704734 countsByYear W20047047342012 @default.
• W2004704734 countsByYear W20047047342013 @default.
• W2004704734 countsByYear W20047047342014 @default.
• W2004704734 countsByYear W20047047342015 @default.
• W2004704734 countsByYear W20047047342016 @default.
• W2004704734 countsByYear W20047047342017 @default.
• W2004704734 countsByYear W20047047342018 @default.
• W2004704734 countsByYear W20047047342019 @default.
• W2004704734 countsByYear W20047047342020 @default.
• W2004704734 countsByYear W20047047342021 @default.
• W2004704734 countsByYear W20047047342023 @default.
• W2004704734 crossrefType "journal-article" @default.
• W2004704734 hasAuthorship W2004704734A5000919272 @default.
• W2004704734 hasAuthorship W2004704734A5007020491 @default.
• W2004704734 hasAuthorship W2004704734A5007869873 @default.
• W2004704734 hasAuthorship W2004704734A5008972554 @default.
• W2004704734 hasAuthorship W2004704734A5039155716 @default.
• W2004704734 hasAuthorship W2004704734A5055386038 @default.
• W2004704734 hasAuthorship W2004704734A5057107186 @default.
• W2004704734 hasAuthorship W2004704734A5070415173 @default.

• next