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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004707433> ?p ?o ?g. }

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• W2004707433 abstract "A novel series of 1,6-dihydro-2H-indeno[5,4-b]furan derivatives were designed and synthesized as MT2-selective ligands. This scaffold was identified as a potent mimic of the 5-methoxy indole core of melatonin, and introduction of a cyclohexylmethyl group at the 7-position of this scaffold afforded an MT2-selective ligand 15 (Ki = 0.012 nM) with high MT1/MT2 selectivity (799). Compound 15 was identified as a potent full agonist for the MT2 subtype and exhibited reentrainment effects to a new light/dark cycle in ICR mice at 3−30 mg/kg. This result demonstrated the involvement of the MT2 receptors in chronobiotic activity." @default.
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• W2004707433 date "2011-04-07" @default.
• W2004707433 modified "2023-09-23" @default.
• W2004707433 title "1,6-Dihydro-2<i>H</i>-indeno[5,4-<i>b</i>]furan Derivatives: Design, Synthesis, and Pharmacological Characterization of a Novel Class of Highly Potent MT₂-Selective Agonists" @default.
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• W2004707433 doi "https://doi.org/10.1021/jm200221q" @default.
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