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- W2004709105 abstract "Genital tract secretions exhibit antimicrobial activity against pathogens including E. coli, which may prevent colonization and infection. We hypothesize that this innate defense may be modulated during pregnancy and may play an important role in preventing chorioamnionitis and neonatal infections. The purpose of this study is to compare endogenous anti-E. coli activity and concentrations of soluble mucosal immune mediators in female genital tract secretions of pregnant and non-pregnant women. 70 pregnant women were recruited during the third trimester of pregnancy and 70 non-pregnant healthy controls are being recruited during a routine gynecological visit. Secretions are collected by vaginal swab, clarified by brief centrifugation, and the supernatants divided into aliquots and stored at −80°C. Anti-E. coli activity is determined using an established colony forming unit assay. The total protein is measured and concentrations of defensins, secretory leukocyte protease inhibitor and cytokines/chemokines measured by ELISA or multiplex Luminex assay. A second vaginal swab is cultured for E. coli. 70 pregnant women and 15 non-pregnant women have completed the study. The pregnant women had significantly higher anti-E.coli activity than the non-pregnant women (median (IQR) 64.5% (30-91) vs 20% (−15-42); p<0.0001, see Figure 1). The concentration of SLPI, an anti-inflammatory protein, was lower in the pregnant compared to non-pregnant women (median (IQR) 211.4 ng/ml (81-728.7) vs. 638.9 ng/ml (38.2-1368); p=0.14). These findings are consistent with an increase in inflammatory cytokines also observed during the third trimester of pregnancy. Pregnancy is associated with higher endogenous activity against E. coli in the genital tract as compared to non-pregnant women. The enhanced activity may provide protection and could serve as a biomarker to identify those women at increased risk of colonization, chorioamnionitis, and perinatal infection." @default.
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- W2004709105 date "2012-01-01" @default.
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- W2004709105 title "590: Increased anti-E. coli activity in the genital tract of pregnant compared to non-pregnant women" @default.
- W2004709105 doi "https://doi.org/10.1016/j.ajog.2011.10.608" @default.
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