Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004709232> ?p ?o ?g. }
- W2004709232 endingPage "e81805" @default.
- W2004709232 startingPage "e81805" @default.
- W2004709232 abstract "The presence of abnormal hematologic findings such as lymphopenia, thrombocytopenia, and pancytopenia were diagnosed in severe cases of avian influenza A H5N1. Whether direct viral dissemination to bone marrow (BM) cells causes this phenomenon remains elusive. We explore the susceptibility of the two stem cell types; hematopoietic stem cells (HSCs) and mesenchymal stromal cells (MSCs) isolated from human BM cells or cord blood, to infection with avian H5N1 viruses. For the first time, we demonstrated that the H5N1 virus could productively infect and induce cell death in both human stem cell types. In contrast, these activities were not observed upon human influenza virus infection. We also determined whether infection affects the immunomodulatory function of MSCs. We noted a consequent dysregulation of MSC-mediated immune modulation as observed by high cytokine and chemokine production in H5N1 infected MSCs and monocytes cocultures. These findings provide a better understanding of H5N1 pathogenesis in terms of broad tissue tropism and systemic spread." @default.
- W2004709232 created "2016-06-24" @default.
- W2004709232 creator A5016338003 @default.
- W2004709232 creator A5027042022 @default.
- W2004709232 creator A5049179921 @default.
- W2004709232 creator A5057999283 @default.
- W2004709232 creator A5070798968 @default.
- W2004709232 creator A5071779518 @default.
- W2004709232 date "2013-12-10" @default.
- W2004709232 modified "2023-09-23" @default.
- W2004709232 title "Tropism of Avian Influenza A (H5N1) Virus to Mesenchymal Stem Cells and CD34+ Hematopoietic Stem Cells" @default.
- W2004709232 cites W1484061442 @default.
- W2004709232 cites W1523679951 @default.
- W2004709232 cites W1965425745 @default.
- W2004709232 cites W1978658172 @default.
- W2004709232 cites W1979043688 @default.
- W2004709232 cites W1980221885 @default.
- W2004709232 cites W1982392051 @default.
- W2004709232 cites W1986601698 @default.
- W2004709232 cites W1988436330 @default.
- W2004709232 cites W1995616397 @default.
- W2004709232 cites W1996311210 @default.
- W2004709232 cites W1999192293 @default.
- W2004709232 cites W2005943573 @default.
- W2004709232 cites W2007785534 @default.
- W2004709232 cites W2011390540 @default.
- W2004709232 cites W2013758266 @default.
- W2004709232 cites W2029383060 @default.
- W2004709232 cites W2029810059 @default.
- W2004709232 cites W2036659405 @default.
- W2004709232 cites W2039396493 @default.
- W2004709232 cites W2046568151 @default.
- W2004709232 cites W2057700014 @default.
- W2004709232 cites W2058131526 @default.
- W2004709232 cites W2074108669 @default.
- W2004709232 cites W2087094669 @default.
- W2004709232 cites W2088402140 @default.
- W2004709232 cites W2095072844 @default.
- W2004709232 cites W2095666785 @default.
- W2004709232 cites W2101490573 @default.
- W2004709232 cites W2102832534 @default.
- W2004709232 cites W2111727066 @default.
- W2004709232 cites W2112271653 @default.
- W2004709232 cites W2117850680 @default.
- W2004709232 cites W2118934189 @default.
- W2004709232 cites W2122399224 @default.
- W2004709232 cites W2123708733 @default.
- W2004709232 cites W2124122135 @default.
- W2004709232 cites W2128070330 @default.
- W2004709232 cites W2129375624 @default.
- W2004709232 cites W2129834060 @default.
- W2004709232 cites W2131683624 @default.
- W2004709232 cites W2132527856 @default.
- W2004709232 cites W2143232661 @default.
- W2004709232 cites W2147061961 @default.
- W2004709232 cites W2153016470 @default.
- W2004709232 cites W2161497340 @default.
- W2004709232 cites W2165647634 @default.
- W2004709232 cites W2168238415 @default.
- W2004709232 cites W2169037579 @default.
- W2004709232 cites W2765197839 @default.
- W2004709232 doi "https://doi.org/10.1371/journal.pone.0081805" @default.
- W2004709232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3858287" @default.
- W2004709232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24339969" @default.
- W2004709232 hasPublicationYear "2013" @default.
- W2004709232 type Work @default.
- W2004709232 sameAs 2004709232 @default.
- W2004709232 citedByCount "23" @default.
- W2004709232 countsByYear W20047092322015 @default.
- W2004709232 countsByYear W20047092322017 @default.
- W2004709232 countsByYear W20047092322018 @default.
- W2004709232 countsByYear W20047092322020 @default.
- W2004709232 countsByYear W20047092322021 @default.
- W2004709232 countsByYear W20047092322022 @default.
- W2004709232 countsByYear W20047092322023 @default.
- W2004709232 crossrefType "journal-article" @default.
- W2004709232 hasAuthorship W2004709232A5016338003 @default.
- W2004709232 hasAuthorship W2004709232A5027042022 @default.
- W2004709232 hasAuthorship W2004709232A5049179921 @default.
- W2004709232 hasAuthorship W2004709232A5057999283 @default.
- W2004709232 hasAuthorship W2004709232A5070798968 @default.
- W2004709232 hasAuthorship W2004709232A5071779518 @default.
- W2004709232 hasBestOaLocation W20047092321 @default.
- W2004709232 hasConcept C10205521 @default.
- W2004709232 hasConcept C109159458 @default.
- W2004709232 hasConcept C13373296 @default.
- W2004709232 hasConcept C159047783 @default.
- W2004709232 hasConcept C198826908 @default.
- W2004709232 hasConcept C203014093 @default.
- W2004709232 hasConcept C2522874641 @default.
- W2004709232 hasConcept C2777546802 @default.
- W2004709232 hasConcept C2778086970 @default.
- W2004709232 hasConcept C2779382419 @default.
- W2004709232 hasConcept C2780007613 @default.
- W2004709232 hasConcept C28328180 @default.
- W2004709232 hasConcept C33602714 @default.
- W2004709232 hasConcept C35693153 @default.
- W2004709232 hasConcept C519248777 @default.