FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004732734> ?p ?o ?g. }

• W2004732734 endingPage "1989" @default.
• W2004732734 startingPage "1980" @default.
• W2004732734 abstract "To investigate whether antibodies to a T14 anti-DNA antibody can be found in patients with systemic lupus erythematosus (SLE).Seventy-six serum samples (37 from patients with SLE) were randomly selected from among sera submitted for routine antinuclear antibody testing. Short, overlapping peptides based on the partial VH (variable region of the heavy chain) sequence of the T14 antibody were synthesized on multipins and screened for reactivity with SLE sera. In addition, selected peptides from T14 and related proteins were synthesized in bulk and screened for reactivity with both SLE and control sera. A monoclonal antibody was generated to determine the prevalence of the T14 idiotype (T14+ Id) in the different study populations.Antibodies were detected by a peptide based on the third complementarity-determining region (CDR3) of the T14 protein in 15 (41%) of 37 patients with SLE or 15 (54%) of 28 who had anti-DNA antibodies, in 3 (9%) of 34 patients without anti-DNA antibodies (9 of whom had SLE), and in 6 (10%) of 57 healthy controls. In SLE sera, the antiidiotypic (anti-Id) responses (IgM and IgG) correlated well with the anti-DNA responses (IgG), and both responses correlated well with the T14+ Id activity in SLE sera. Control peptides based on the 18/2 (16/6+ Id) and S107 proteins detected low antibody activities in SLE sera, attributable to cross-reactivity with the T14 peptide. A peptide based on an unrelated human antibody was not reactive with these sera.Anti-Id antibodies directed to T14 VHCDR3 were found commonly in the sera of patients with SLE, and they appeared to be induced by the anti-DNA antibodies present in the sera. Based on these findings, these secondary antibodies may be pathogenic in SLE." @default.
• W2004732734 created "2016-06-24" @default.
• W2004732734 creator A5017803854 @default.
• W2004732734 creator A5047974488 @default.
• W2004732734 creator A5051763034 @default.
• W2004732734 creator A5054681086 @default.
• W2004732734 creator A5056977470 @default.
• W2004732734 creator A5061724950 @default.
• W2004732734 creator A5062992246 @default.
• W2004732734 creator A5066233766 @default.
• W2004732734 creator A5084134590 @default.
• W2004732734 date "1996-12-01" @default.
• W2004732734 modified "2023-10-15" @default.
• W2004732734 title "Common occurrence of an antiidiotypic antibody that recognizes T14+ anti-DNA antibodies in patients with systemic lupus erythematosus" @default.
• W2004732734 cites W1938885059 @default.
• W2004732734 cites W1965968572 @default.
• W2004732734 cites W1969827761 @default.
• W2004732734 cites W1975906233 @default.
• W2004732734 cites W1979160057 @default.
• W2004732734 cites W2004879566 @default.
• W2004732734 cites W2014207178 @default.
• W2004732734 cites W2035209074 @default.
• W2004732734 cites W2055280685 @default.
• W2004732734 cites W2055708140 @default.
• W2004732734 cites W2055800192 @default.
• W2004732734 cites W2058962713 @default.
• W2004732734 cites W2064521610 @default.
• W2004732734 cites W2080839248 @default.
• W2004732734 cites W2085917951 @default.
• W2004732734 cites W2088125002 @default.
• W2004732734 cites W2088339535 @default.
• W2004732734 cites W2089194602 @default.
• W2004732734 cites W2090310103 @default.
• W2004732734 cites W2092006031 @default.
• W2004732734 cites W2103470182 @default.
• W2004732734 cites W2110736244 @default.
• W2004732734 cites W2113059823 @default.
• W2004732734 cites W2119832072 @default.
• W2004732734 cites W2139223118 @default.
• W2004732734 cites W2142466602 @default.
• W2004732734 cites W2145361353 @default.
• W2004732734 cites W2146203649 @default.
• W2004732734 cites W2162320902 @default.
• W2004732734 doi "https://doi.org/10.1002/art.1780391206" @default.
• W2004732734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8961902" @default.
• W2004732734 hasPublicationYear "1996" @default.
• W2004732734 type Work @default.
• W2004732734 sameAs 2004732734 @default.
• W2004732734 citedByCount "4" @default.
• W2004732734 crossrefType "journal-article" @default.
• W2004732734 hasAuthorship W2004732734A5017803854 @default.
• W2004732734 hasAuthorship W2004732734A5047974488 @default.
• W2004732734 hasAuthorship W2004732734A5051763034 @default.
• W2004732734 hasAuthorship W2004732734A5054681086 @default.
• W2004732734 hasAuthorship W2004732734A5056977470 @default.
• W2004732734 hasAuthorship W2004732734A5061724950 @default.
• W2004732734 hasAuthorship W2004732734A5062992246 @default.
• W2004732734 hasAuthorship W2004732734A5066233766 @default.
• W2004732734 hasAuthorship W2004732734A5084134590 @default.
• W2004732734 hasConcept C149443304 @default.
• W2004732734 hasConcept C159654299 @default.
• W2004732734 hasConcept C163764329 @default.
• W2004732734 hasConcept C203014093 @default.
• W2004732734 hasConcept C2775915377 @default.
• W2004732734 hasConcept C2910082366 @default.
• W2004732734 hasConcept C542903549 @default.
• W2004732734 hasConcept C71924100 @default.
• W2004732734 hasConcept C74505204 @default.
• W2004732734 hasConceptScore W2004732734C149443304 @default.
• W2004732734 hasConceptScore W2004732734C159654299 @default.
• W2004732734 hasConceptScore W2004732734C163764329 @default.
• W2004732734 hasConceptScore W2004732734C203014093 @default.
• W2004732734 hasConceptScore W2004732734C2775915377 @default.
• W2004732734 hasConceptScore W2004732734C2910082366 @default.
• W2004732734 hasConceptScore W2004732734C542903549 @default.
• W2004732734 hasConceptScore W2004732734C71924100 @default.
• W2004732734 hasConceptScore W2004732734C74505204 @default.
• W2004732734 hasIssue "12" @default.
• W2004732734 hasLocation W20047327341 @default.
• W2004732734 hasLocation W20047327342 @default.
• W2004732734 hasOpenAccess W2004732734 @default.
• W2004732734 hasPrimaryLocation W20047327341 @default.
• W2004732734 hasRelatedWork W1963734927 @default.
• W2004732734 hasRelatedWork W1987381631 @default.
• W2004732734 hasRelatedWork W1988695352 @default.
• W2004732734 hasRelatedWork W2004732734 @default.
• W2004732734 hasRelatedWork W2005086657 @default.
• W2004732734 hasRelatedWork W2042253682 @default.
• W2004732734 hasRelatedWork W2400126894 @default.
• W2004732734 hasRelatedWork W2405627905 @default.
• W2004732734 hasRelatedWork W57491688 @default.
• W2004732734 hasRelatedWork W17953441 @default.
• W2004732734 hasVolume "39" @default.
• W2004732734 isParatext "false" @default.
• W2004732734 isRetracted "false" @default.
• W2004732734 magId "2004732734" @default.
• W2004732734 workType "article" @default.