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• W2004732764 endingPage "191" @default.
• W2004732764 startingPage "181" @default.
• W2004732764 abstract "Low molecular weight Rho GTPases are proteins that, in response to diverse stimuli, control key cellular processes such as cell proliferation, apoptosis, lipid metabolism, cytoarchitecture, adhesion, migration, cell polarity, and transcriptional regulation. The high incidence of overexpression of some members of the Rho family of GTPases in human tumors suggests that these proteins are important in the carcinogenic process, and therefore potential candidates for a therapeutic intervention. In recent years, the characterization of downstream effectors to Rho GTPases has increased our understanding of the general cellular effects that permit aberrant proliferation and motility of tumor cells. In addition, several transcription factors have been identified to play important roles at various levels of Rho-induced tumorigenesis. Accordingly, drugs that specifically alter Rho signaling display antineoplastic properties both at the level of tumor growth and tumor metastasis. In this review, a brief summary of the progress made in understanding the biological functions elicited by Rho GTPases that contribute to tumor biology will be made. In addition, a description of new drugs available targeted to specific elements of Rho signaling with antineoplastic or antimetastatic activity is included." @default.
• W2004732764 created "2016-06-24" @default.
• W2004732764 creator A5004990254 @default.
• W2004732764 creator A5016972421 @default.
• W2004732764 creator A5054941477 @default.
• W2004732764 creator A5069282023 @default.
• W2004732764 date "2004-04-01" @default.
• W2004732764 modified "2023-10-17" @default.
• W2004732764 title "Rho GTPases: potential candidates for anticancer therapy" @default.
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