FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004734985> ?p ?o ?g. }

• W2004734985 endingPage "186" @default.
• W2004734985 startingPage "175" @default.
• W2004734985 abstract "Water accumulation in retinal glial (Müller) and neuronal cells resulting in cellular swelling contributes to the development of retinal edema and neurodegeneration. Intravitreal administration of neurotrophins such as brain-derived neurotrophic factor (BDNF) is known to promote survival of retinal neurons. Here, we show that exogenous BDNF inhibits the osmotic swelling of Müller cell somata induced by superfusion of rat retinal slices or freshly isolated cells with a hypoosmotic solution containing barium ions. BDNF also inhibited the osmotic swelling of bipolar cell somata in retinal slices, but failed to inhibit the osmotic soma swelling of freshly isolated bipolar cells. The inhibitory effect of BDNF on Müller cell swelling was mediated by activation of tropomyosin-related kinase B (TrkB) and transactivation of fibroblast growth factor receptors. Exogenous basic fibroblast growth factor (bFGF) fully inhibited the osmotic swelling of Müller cell somata while it partially inhibited the osmotic swelling of bipolar cell somata. Isolated Müller cells displayed immunoreactivity of truncated TrkB, but not full-length TrkB. Isolated rod bipolar cells displayed immunoreactivities of both TrkB isoforms. Data suggest that the neuroprotective effect of exogenous BDNF in the retina is in part mediated by prevention of the cytotoxic swelling of retinal glial and bipolar cells. While BDNF directly acts on Müller cells by activation of TrkB, BDNF indirectly acts on bipolar cells by inducing glial release of factors like bFGF that inhibit bipolar cell swelling." @default.
• W2004734985 created "2016-06-24" @default.
• W2004734985 creator A5006741407 @default.
• W2004734985 creator A5010651047 @default.
• W2004734985 creator A5017649992 @default.
• W2004734985 creator A5018272749 @default.
• W2004734985 creator A5045138697 @default.
• W2004734985 creator A5049584641 @default.
• W2004734985 creator A5068456297 @default.
• W2004734985 creator A5068639404 @default.
• W2004734985 creator A5085037030 @default.
• W2004734985 date "2015-06-01" @default.
• W2004734985 modified "2023-10-09" @default.
• W2004734985 title "Brain-derived neurotrophic factor inhibits osmotic swelling of rat retinal glial (Müller) and bipolar cells by activation of basic fibroblast growth factor signaling" @default.
• W2004734985 cites W1488489148 @default.
• W2004734985 cites W1499221875 @default.
• W2004734985 cites W1556783877 @default.
• W2004734985 cites W1861582625 @default.
• W2004734985 cites W1969811289 @default.
• W2004734985 cites W1974084948 @default.
• W2004734985 cites W1974549138 @default.
• W2004734985 cites W1975423239 @default.
• W2004734985 cites W1977446607 @default.
• W2004734985 cites W1977999433 @default.
• W2004734985 cites W1979534828 @default.
• W2004734985 cites W1988186209 @default.
• W2004734985 cites W1988524644 @default.
• W2004734985 cites W1989490743 @default.
• W2004734985 cites W1994038425 @default.
• W2004734985 cites W1997006929 @default.
• W2004734985 cites W1998349911 @default.
• W2004734985 cites W2000079550 @default.
• W2004734985 cites W2004947473 @default.
• W2004734985 cites W2014949766 @default.
• W2004734985 cites W2020540426 @default.
• W2004734985 cites W2021299834 @default.
• W2004734985 cites W2021497853 @default.
• W2004734985 cites W2023715580 @default.
• W2004734985 cites W2042896852 @default.
• W2004734985 cites W2045805322 @default.
• W2004734985 cites W2048747712 @default.
• W2004734985 cites W2049818109 @default.
• W2004734985 cites W2050117642 @default.
• W2004734985 cites W2050857698 @default.
• W2004734985 cites W2055867785 @default.
• W2004734985 cites W2057777152 @default.
• W2004734985 cites W2058159732 @default.
• W2004734985 cites W2061235009 @default.
• W2004734985 cites W2065162572 @default.
• W2004734985 cites W2073137578 @default.
• W2004734985 cites W2080816502 @default.
• W2004734985 cites W2082739481 @default.
• W2004734985 cites W2087953635 @default.
• W2004734985 cites W2096950509 @default.
• W2004734985 cites W2097184741 @default.
• W2004734985 cites W2104590670 @default.
• W2004734985 cites W2104678075 @default.
• W2004734985 cites W2116050939 @default.
• W2004734985 cites W2119207529 @default.
• W2004734985 cites W2122127855 @default.
• W2004734985 cites W2122565496 @default.
• W2004734985 cites W2126714637 @default.
• W2004734985 cites W2131307995 @default.
• W2004734985 cites W2131612987 @default.
• W2004734985 cites W2134710513 @default.
• W2004734985 cites W2154127992 @default.
• W2004734985 cites W2170570726 @default.
• W2004734985 doi "https://doi.org/10.1016/j.neuroscience.2015.03.037" @default.
• W2004734985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25813711" @default.
• W2004734985 hasPublicationYear "2015" @default.
• W2004734985 type Work @default.
• W2004734985 sameAs 2004734985 @default.
• W2004734985 citedByCount "21" @default.
• W2004734985 countsByYear W20047349852015 @default.
• W2004734985 countsByYear W20047349852016 @default.
• W2004734985 countsByYear W20047349852017 @default.
• W2004734985 countsByYear W20047349852018 @default.
• W2004734985 countsByYear W20047349852019 @default.
• W2004734985 countsByYear W20047349852020 @default.
• W2004734985 countsByYear W20047349852021 @default.
• W2004734985 countsByYear W20047349852022 @default.
• W2004734985 countsByYear W20047349852023 @default.
• W2004734985 crossrefType "journal-article" @default.
• W2004734985 hasAuthorship W2004734985A5006741407 @default.
• W2004734985 hasAuthorship W2004734985A5010651047 @default.
• W2004734985 hasAuthorship W2004734985A5017649992 @default.
• W2004734985 hasAuthorship W2004734985A5018272749 @default.
• W2004734985 hasAuthorship W2004734985A5045138697 @default.
• W2004734985 hasAuthorship W2004734985A5049584641 @default.
• W2004734985 hasAuthorship W2004734985A5068456297 @default.
• W2004734985 hasAuthorship W2004734985A5068639404 @default.
• W2004734985 hasAuthorship W2004734985A5085037030 @default.
• W2004734985 hasConcept C160539049 @default.
• W2004734985 hasConcept C169760540 @default.
• W2004734985 hasConcept C170493617 @default.
• W2004734985 hasConcept C185592680 @default.
• W2004734985 hasConcept C2775960820 @default.
• W2004734985 hasConcept C2777093970 @default.

• next