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- W2004738728 startingPage "169" @default.
- W2004738728 abstract "Abstract A wide variety of phenolic compounds derived from spices possess potent antioxidant, anti‐inflammatory, antimutagenic, and anticarcinogenic activities. [6]‐gingerol (1‐[4′‐hydroxy‐3′‐methoxyphenyl]‐5‐hydroxy‐3‐decanone) is the major pungent principle of ginger, with numerous pharmacological properties including antioxidant, anti‐inflammation, and antitumor promoting properties. It could decrease inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF‐α) expression through suppression of I‐kappaB alpha (IκBα) phosphorylation, nuclear factor kappa B (NF‐κB) nuclear translocation. Other antiproliferative mechanisms of [6]‐gingerol include the release of Cytochrome c, Caspases activation, and increase in apoptotic protease‐activating factor‐1 (Apaf‐1) as mechanism of apoptosis induction. Taken together, the chemopreventive potentials of [6]‐gingerol present a promising future alternative to therapeutic agents that are expensive, toxic, and might even be carcinogenic." @default.
- W2004738728 created "2016-06-24" @default.
- W2004738728 creator A5008790605 @default.
- W2004738728 creator A5016177146 @default.
- W2004738728 creator A5043404389 @default.
- W2004738728 date "2010-03-15" @default.
- W2004738728 modified "2023-10-17" @default.
- W2004738728 title "Molecular targets of [6]‐gingerol: Its potential roles in cancer chemoprevention" @default.
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