FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004742827> ?p ?o ?g. }

• W2004742827 endingPage "1459" @default.
• W2004742827 startingPage "1451" @default.
• W2004742827 abstract "Organic peroxides are widely used in the chemical industry as initiators of oxidation for the production of polymers and fiber-reinforced plastics, in the manufacture of polyester resin coatings, and pharmaceuticals. Free radical production is considered to be one of the key factors contributing to skin tumor promotion by organic peroxides. In vitro experiments have demonstrated metal-catalyzed formation of alkoxyl, alkyl, and aryl radicals in keratinocytes incubated with cumene hydroperoxide. The present study investigated in vivo free radical generation in lipid extracts of mouse skin exposed to cumene hydroperoxide. The electron spin resonance (ESR) spin-trapping technique was used to detect the formation of alpha-phenyl-N-tert-butylnitrone (PBN) radical adducts, following intradermal injection of 180 mg/kg PBN. It was found that 30 min after topical exposure, cumene hydroperoxide (12 mmol/kg) induced free radical generation in the skin of female Balb/c mice kept for 10 weeks on vitamin E-deficient diets. In contrast, hardly discernible radical adducts were detected when cumene hydroperoxide was applied to the skin of mice fed a vitamin E-sufficient diet. Importantly, total antioxidant reserve and levels of GSH, ascorbate, and vitamin E decreased 34%, 46.5%. 27%, and 98%, respectively, after mice were kept for 10 weeks on vitamin E-deficient diet. PBN adducts detected by ESR in vitamin E-deficient mice provide direct evidence for in vivo free radical generation in the skin after exposure to cumene hydroperoxide." @default.
• W2004742827 created "2016-06-24" @default.
• W2004742827 creator A5002789102 @default.
• W2004742827 creator A5006031913 @default.
• W2004742827 creator A5015414029 @default.
• W2004742827 creator A5018151824 @default.
• W2004742827 creator A5038216324 @default.
• W2004742827 creator A5040826563 @default.
• W2004742827 creator A5061910944 @default.
• W2004742827 creator A5069406228 @default.
• W2004742827 date "2002-10-18" @default.
• W2004742827 modified "2023-09-26" @default.
• W2004742827 title "Antioxidant Balance and Free Radical Generation in Vitamin E-Deficient Mice after Dermal Exposure to Cumene Hydroperoxide" @default.
• W2004742827 cites W1488616816 @default.
• W2004742827 cites W1583486332 @default.
• W2004742827 cites W1837548641 @default.
• W2004742827 cites W1867329478 @default.
• W2004742827 cites W1973359682 @default.
• W2004742827 cites W1977109446 @default.
• W2004742827 cites W1999472738 @default.
• W2004742827 cites W2008346365 @default.
• W2004742827 cites W2010513000 @default.
• W2004742827 cites W2014237455 @default.
• W2004742827 cites W2017408327 @default.
• W2004742827 cites W2041475540 @default.
• W2004742827 cites W2042558624 @default.
• W2004742827 cites W2045754313 @default.
• W2004742827 cites W2050474612 @default.
• W2004742827 cites W2079397201 @default.
• W2004742827 cites W2088689189 @default.
• W2004742827 cites W2100319265 @default.
• W2004742827 cites W2108267526 @default.
• W2004742827 cites W2168526937 @default.
• W2004742827 cites W2313317340 @default.
• W2004742827 doi "https://doi.org/10.1021/tx0200313" @default.
• W2004742827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12437336" @default.
• W2004742827 hasPublicationYear "2002" @default.
• W2004742827 type Work @default.
• W2004742827 sameAs 2004742827 @default.
• W2004742827 citedByCount "23" @default.
• W2004742827 countsByYear W20047428272014 @default.
• W2004742827 countsByYear W20047428272015 @default.
• W2004742827 countsByYear W20047428272016 @default.
• W2004742827 countsByYear W20047428272018 @default.
• W2004742827 countsByYear W20047428272019 @default.
• W2004742827 countsByYear W20047428272022 @default.
• W2004742827 crossrefType "journal-article" @default.
• W2004742827 hasAuthorship W2004742827A5002789102 @default.
• W2004742827 hasAuthorship W2004742827A5006031913 @default.
• W2004742827 hasAuthorship W2004742827A5015414029 @default.
• W2004742827 hasAuthorship W2004742827A5018151824 @default.
• W2004742827 hasAuthorship W2004742827A5038216324 @default.
• W2004742827 hasAuthorship W2004742827A5040826563 @default.
• W2004742827 hasAuthorship W2004742827A5061910944 @default.
• W2004742827 hasAuthorship W2004742827A5069406228 @default.
• W2004742827 hasConcept C139066938 @default.
• W2004742827 hasConcept C150903083 @default.
• W2004742827 hasConcept C161790260 @default.
• W2004742827 hasConcept C185592680 @default.
• W2004742827 hasConcept C207001950 @default.
• W2004742827 hasConcept C2776778087 @default.
• W2004742827 hasConcept C2776940978 @default.
• W2004742827 hasConcept C2777551382 @default.
• W2004742827 hasConcept C2778004101 @default.
• W2004742827 hasConcept C2778113725 @default.
• W2004742827 hasConcept C2778215507 @default.
• W2004742827 hasConcept C2778815226 @default.
• W2004742827 hasConcept C55493867 @default.
• W2004742827 hasConcept C75473681 @default.
• W2004742827 hasConcept C86803240 @default.
• W2004742827 hasConceptScore W2004742827C139066938 @default.
• W2004742827 hasConceptScore W2004742827C150903083 @default.
• W2004742827 hasConceptScore W2004742827C161790260 @default.
• W2004742827 hasConceptScore W2004742827C185592680 @default.
• W2004742827 hasConceptScore W2004742827C207001950 @default.
• W2004742827 hasConceptScore W2004742827C2776778087 @default.
• W2004742827 hasConceptScore W2004742827C2776940978 @default.
• W2004742827 hasConceptScore W2004742827C2777551382 @default.
• W2004742827 hasConceptScore W2004742827C2778004101 @default.
• W2004742827 hasConceptScore W2004742827C2778113725 @default.
• W2004742827 hasConceptScore W2004742827C2778215507 @default.
• W2004742827 hasConceptScore W2004742827C2778815226 @default.
• W2004742827 hasConceptScore W2004742827C55493867 @default.
• W2004742827 hasConceptScore W2004742827C75473681 @default.
• W2004742827 hasConceptScore W2004742827C86803240 @default.
• W2004742827 hasIssue "11" @default.
• W2004742827 hasLocation W20047428271 @default.
• W2004742827 hasLocation W20047428272 @default.
• W2004742827 hasOpenAccess W2004742827 @default.
• W2004742827 hasPrimaryLocation W20047428271 @default.
• W2004742827 hasRelatedWork W134642537 @default.
• W2004742827 hasRelatedWork W1965962699 @default.
• W2004742827 hasRelatedWork W1968477076 @default.
• W2004742827 hasRelatedWork W2003726901 @default.
• W2004742827 hasRelatedWork W2012963666 @default.
• W2004742827 hasRelatedWork W2032846370 @default.
• W2004742827 hasRelatedWork W2053381403 @default.
• W2004742827 hasRelatedWork W2188567860 @default.

• next