Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004743669> ?p ?o ?g. }
- W2004743669 endingPage "1027" @default.
- W2004743669 startingPage "1019" @default.
- W2004743669 abstract "Purpose: To investigate the ability of human lymphocytes labeled with DNA-incorporated 125I to exert an inhibitory (antiproliferative) bystander effect on co-cultured human colon adenocarcinoma LS174T cells in vitro.Materials and methods: Human peripheral blood lymphocytes were stimulated to synthesize DNA in the presence of phytohemagglutinin (PHA) and labeled with 5-[125I]iodo-2′-deoxyuridine. Human colon adenocarcinoma LS174T cells were co-cultured with the 125I-labeled lymphocytes in various ratios for 5 days and the proliferation of the LS174T cells was assessed. Further, the supernatant media from these co-cultures were: (i) Transferred to LS174T cells and their proliferation measured after 5 days, (ii) used to assess the clonogenic survival of LS174T cells, and (iii) screened for factors that suppress growth.Results: A significant reduction in the proliferation of LS174T cells was observed when co-cultured either with 125I-labeled lymphocytes (56 ± 3.5%) or the supernatant media (52.5 ± 1.3%) obtained from these co-cultures. Clonogenic survival of LS174T cells grown in the supernatant media corroborated the decrease in tumor cell growth.Conclusion: The observed reduction in the proliferation of LS174T cells in presence of 125I-labeled lymphocytes or media obtained from such co-cultures can be attributed to an inhibitory (antiproliferative) bystander effect, probably mediated by factor(s) released from the dying 125I-labeled lymphocytes." @default.
- W2004743669 created "2016-06-24" @default.
- W2004743669 creator A5004556224 @default.
- W2004743669 creator A5011834461 @default.
- W2004743669 creator A5070416441 @default.
- W2004743669 creator A5074199227 @default.
- W2004743669 creator A5086063752 @default.
- W2004743669 date "2012-07-09" @default.
- W2004743669 modified "2023-10-13" @default.
- W2004743669 title "Bystander effect in tumor cells produced by Iodine-125 labeled human lymphocytes" @default.
- W2004743669 cites W1816472901 @default.
- W2004743669 cites W1973296540 @default.
- W2004743669 cites W1975097885 @default.
- W2004743669 cites W1975447309 @default.
- W2004743669 cites W1976615745 @default.
- W2004743669 cites W1998259375 @default.
- W2004743669 cites W2000371134 @default.
- W2004743669 cites W2000477606 @default.
- W2004743669 cites W2000985369 @default.
- W2004743669 cites W2009778750 @default.
- W2004743669 cites W2011465438 @default.
- W2004743669 cites W2011474487 @default.
- W2004743669 cites W2018820070 @default.
- W2004743669 cites W2027329004 @default.
- W2004743669 cites W2031410933 @default.
- W2004743669 cites W2031575255 @default.
- W2004743669 cites W2034470420 @default.
- W2004743669 cites W2035754366 @default.
- W2004743669 cites W2042636139 @default.
- W2004743669 cites W2047551799 @default.
- W2004743669 cites W2047636094 @default.
- W2004743669 cites W2049341844 @default.
- W2004743669 cites W2049863710 @default.
- W2004743669 cites W2054797238 @default.
- W2004743669 cites W2056285234 @default.
- W2004743669 cites W2060057454 @default.
- W2004743669 cites W2073174869 @default.
- W2004743669 cites W2073946113 @default.
- W2004743669 cites W2074542958 @default.
- W2004743669 cites W2090850307 @default.
- W2004743669 cites W2096652409 @default.
- W2004743669 cites W2101331356 @default.
- W2004743669 cites W2111554139 @default.
- W2004743669 cites W2115557090 @default.
- W2004743669 cites W2118267837 @default.
- W2004743669 cites W2119050264 @default.
- W2004743669 cites W2129903518 @default.
- W2004743669 cites W2140863655 @default.
- W2004743669 cites W2144548733 @default.
- W2004743669 cites W2150949864 @default.
- W2004743669 cites W2153327231 @default.
- W2004743669 cites W2159886619 @default.
- W2004743669 cites W2164856505 @default.
- W2004743669 cites W2170039563 @default.
- W2004743669 cites W2184416722 @default.
- W2004743669 cites W2195490444 @default.
- W2004743669 cites W2314399086 @default.
- W2004743669 cites W2319895613 @default.
- W2004743669 cites W4298191748 @default.
- W2004743669 doi "https://doi.org/10.3109/09553002.2012.702297" @default.
- W2004743669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3755763" @default.
- W2004743669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22712702" @default.
- W2004743669 hasPublicationYear "2012" @default.
- W2004743669 type Work @default.
- W2004743669 sameAs 2004743669 @default.
- W2004743669 citedByCount "7" @default.
- W2004743669 countsByYear W20047436692013 @default.
- W2004743669 countsByYear W20047436692015 @default.
- W2004743669 countsByYear W20047436692016 @default.
- W2004743669 countsByYear W20047436692017 @default.
- W2004743669 countsByYear W20047436692019 @default.
- W2004743669 countsByYear W20047436692022 @default.
- W2004743669 crossrefType "journal-article" @default.
- W2004743669 hasAuthorship W2004743669A5004556224 @default.
- W2004743669 hasAuthorship W2004743669A5011834461 @default.
- W2004743669 hasAuthorship W2004743669A5070416441 @default.
- W2004743669 hasAuthorship W2004743669A5074199227 @default.
- W2004743669 hasAuthorship W2004743669A5086063752 @default.
- W2004743669 hasBestOaLocation W20047436692 @default.
- W2004743669 hasConcept C117262875 @default.
- W2004743669 hasConcept C1491633281 @default.
- W2004743669 hasConcept C153911025 @default.
- W2004743669 hasConcept C185592680 @default.
- W2004743669 hasConcept C202751555 @default.
- W2004743669 hasConcept C54355233 @default.
- W2004743669 hasConcept C55493867 @default.
- W2004743669 hasConcept C62112901 @default.
- W2004743669 hasConcept C81885089 @default.
- W2004743669 hasConcept C86803240 @default.
- W2004743669 hasConceptScore W2004743669C117262875 @default.
- W2004743669 hasConceptScore W2004743669C1491633281 @default.
- W2004743669 hasConceptScore W2004743669C153911025 @default.
- W2004743669 hasConceptScore W2004743669C185592680 @default.
- W2004743669 hasConceptScore W2004743669C202751555 @default.
- W2004743669 hasConceptScore W2004743669C54355233 @default.
- W2004743669 hasConceptScore W2004743669C55493867 @default.
- W2004743669 hasConceptScore W2004743669C62112901 @default.
- W2004743669 hasConceptScore W2004743669C81885089 @default.