FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004744807> ?p ?o ?g. }

• W2004744807 endingPage "845" @default.
• W2004744807 startingPage "835" @default.
• W2004744807 abstract "We investigated the effects of a high-fat (HF) diet and peroxisome proliferator-activated receptor (PPAR)-alpha activation on the intrarenal lipotoxicity associated with the renin-angiotensin system (RAS) and oxidative stress using spontaneously hypertensive (SHR) rats. Male SHR and Wistar-Kyoto (WKY) rats at 8 weeks of age were fed either a normal-fat diet or an HF diet without or with fenofibrate treatment for 12 weeks. Severe intrarenal lipid accumulation was noted in the SHR rats fed an HF diet than in WYK rats fed an HF diet (P<0.05). This lipid accumulation was associated with a 70% decrease in renal PPARalpha expression in SHR rats, whereas an HF diet increased the expression of PPARalpha in WKY rats by threefold. An HF diet also activated intrarenal, not systemic, RAS and induced oxidative stress associated with reduced nitric oxide (NO) bioavailability. By contrast, fenofibrate attenuated weight gain, fat mass and insulin resistance. Fenofibrate recovered HF diet-induced decreases in intrarenal PPARalpha expression and fat accumulation, and abolished intrarenal RAS activation and oxidative stress in SHR-HF animals (P<0.01). These activities conferred protection against increased blood pressure (BP), glomerulosclerosis and renal inflammation. Intrarenal free fatty acid and triglyceride concentrations were positively correlated with angiotensin II (gamma=0.63, 0.36) and 24-h urinary 8-hydroxy-deoxyguanosine (gamma=0.36, 0.39), and negatively correlated with PPARalpha contents (gamma=-0.47, -0.44; P<0.05). An HF diet-induced lipotoxicity by depletion of intrarenal PPARalpha aggravated BP and renal inflammation as a result of intrarenal RAS activation and oxidative stress. Therefore, intervention with PPARalpha activators can effectively prevent diet-induced renal lipotoxicity in hypertensive rats." @default.
• W2004744807 created "2016-06-24" @default.
• W2004744807 creator A5008321295 @default.
• W2004744807 creator A5011073372 @default.
• W2004744807 creator A5017354929 @default.
• W2004744807 creator A5028514834 @default.
• W2004744807 creator A5033395489 @default.
• W2004744807 creator A5033725654 @default.
• W2004744807 creator A5065254353 @default.
• W2004744807 creator A5065701558 @default.
• W2004744807 creator A5080395613 @default.
• W2004744807 date "2009-07-31" @default.
• W2004744807 modified "2023-10-13" @default.
• W2004744807 title "Peroxisome proliferator-activated receptor-α activator fenofibrate prevents high-fat diet-induced renal lipotoxicity in spontaneously hypertensive rats" @default.
• W2004744807 cites W1588804421 @default.
• W2004744807 cites W1933040215 @default.
• W2004744807 cites W1966023606 @default.
• W2004744807 cites W1967701810 @default.
• W2004744807 cites W1974238827 @default.
• W2004744807 cites W1977749538 @default.
• W2004744807 cites W1983804278 @default.
• W2004744807 cites W2013665956 @default.
• W2004744807 cites W2016366089 @default.
• W2004744807 cites W2019964412 @default.
• W2004744807 cites W2022636670 @default.
• W2004744807 cites W2028439883 @default.
• W2004744807 cites W2034542419 @default.
• W2004744807 cites W2035536340 @default.
• W2004744807 cites W2038561349 @default.
• W2004744807 cites W2042646534 @default.
• W2004744807 cites W2045930196 @default.
• W2004744807 cites W2053811269 @default.
• W2004744807 cites W2055876681 @default.
• W2004744807 cites W2057142373 @default.
• W2004744807 cites W2071979522 @default.
• W2004744807 cites W2085800400 @default.
• W2004744807 cites W2091296420 @default.
• W2004744807 cites W2099262759 @default.
• W2004744807 cites W2106127329 @default.
• W2004744807 cites W2109938153 @default.
• W2004744807 cites W2119741758 @default.
• W2004744807 cites W2120001839 @default.
• W2004744807 cites W2123546645 @default.
• W2004744807 cites W2126317966 @default.
• W2004744807 cites W2133613922 @default.
• W2004744807 cites W2140161647 @default.
• W2004744807 cites W2141979154 @default.
• W2004744807 cites W2144375073 @default.
• W2004744807 cites W2154388708 @default.
• W2004744807 cites W2156712090 @default.
• W2004744807 cites W2158085355 @default.
• W2004744807 cites W2159168356 @default.
• W2004744807 cites W2163839619 @default.
• W2004744807 cites W2169543873 @default.
• W2004744807 cites W2170101324 @default.
• W2004744807 cites W2170352583 @default.
• W2004744807 cites W2322180243 @default.
• W2004744807 cites W4251119320 @default.
• W2004744807 doi "https://doi.org/10.1038/hr.2009.107" @default.
• W2004744807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19644507" @default.
• W2004744807 hasPublicationYear "2009" @default.
• W2004744807 type Work @default.
• W2004744807 sameAs 2004744807 @default.
• W2004744807 citedByCount "59" @default.
• W2004744807 countsByYear W20047448072012 @default.
• W2004744807 countsByYear W20047448072013 @default.
• W2004744807 countsByYear W20047448072014 @default.
• W2004744807 countsByYear W20047448072015 @default.
• W2004744807 countsByYear W20047448072016 @default.
• W2004744807 countsByYear W20047448072017 @default.
• W2004744807 countsByYear W20047448072018 @default.
• W2004744807 countsByYear W20047448072019 @default.
• W2004744807 countsByYear W20047448072020 @default.
• W2004744807 countsByYear W20047448072021 @default.
• W2004744807 countsByYear W20047448072022 @default.
• W2004744807 countsByYear W20047448072023 @default.
• W2004744807 crossrefType "journal-article" @default.
• W2004744807 hasAuthorship W2004744807A5008321295 @default.
• W2004744807 hasAuthorship W2004744807A5011073372 @default.
• W2004744807 hasAuthorship W2004744807A5017354929 @default.
• W2004744807 hasAuthorship W2004744807A5028514834 @default.
• W2004744807 hasAuthorship W2004744807A5033395489 @default.
• W2004744807 hasAuthorship W2004744807A5033725654 @default.
• W2004744807 hasAuthorship W2004744807A5065254353 @default.
• W2004744807 hasAuthorship W2004744807A5065701558 @default.
• W2004744807 hasAuthorship W2004744807A5080395613 @default.
• W2004744807 hasBestOaLocation W20047448071 @default.
• W2004744807 hasConcept C126322002 @default.
• W2004744807 hasConcept C134018914 @default.
• W2004744807 hasConcept C170493617 @default.
• W2004744807 hasConcept C185592680 @default.
• W2004744807 hasConcept C187345961 @default.
• W2004744807 hasConcept C2776151105 @default.
• W2004744807 hasConcept C2777391703 @default.
• W2004744807 hasConcept C2778110834 @default.
• W2004744807 hasConcept C2778163477 @default.
• W2004744807 hasConcept C2778913445 @default.
• W2004744807 hasConcept C2779306644 @default.

• next