Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004751532> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2004751532 endingPage "284" @default.
- W2004751532 startingPage "275" @default.
- W2004751532 abstract "The ACHE and BCHE genes, encoding the acetylcholine hydrolysing enzymes acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE), co-amplify with several oncogenes in leukemic patients with platelet deficiency (thrombocytopenia). This and other experiments implicated ACHE and BCHE in the development of bone marrow megakaryocytes, the progenitors of platelets. Therefore, we wished to find out whether cholinesterase gene amplification would also occur in non-cancerous platelet disorders and, if so, whether oncogenes would amplify in such cases as well. The autoimmune disease systemic lupus erythematosus (SLE) presents an appropriate model system for this issue, since patients with SLE may suffer from thrombocytopenia resistant to most treatment modalities. Here, we report a 40–80-fold amplification of genomic sequences from the ACHE and BCHE genes as well as the C-raf, V-sis and C-fes/fps oncogenes in peripheral blood cells from an SLE patient with severe thrombocytopenia. PvuII restriction analysis and DNA blot hybridization of the amplified ACHE and BCHE sequences demonstrated apparent aberrations in both genes, suggesting that malfunctioning of modified, partially amplified cholinesterase genes may be involved in the etiology of thrombocytopenia associated with SLE. These observations imply that cholinergic mechanisms regulate megakaryocytopoiesis, shed new light on the diverse hematologic findings characteristic of SLE, and may become valuable as diagnostic, treatment and prognostic tools in the follow-up of patients suffering from thrombocytopenia associated with SLE. Furthermore, these findings reinforce the notion that cholinesterase gene amplifications are causally related with platelet abnormalities in multiple hemopoietic disorders." @default.
- W2004751532 created "2016-06-24" @default.
- W2004751532 creator A5003680413 @default.
- W2004751532 creator A5045895671 @default.
- W2004751532 creator A5051208725 @default.
- W2004751532 creator A5075251637 @default.
- W2004751532 creator A5076319918 @default.
- W2004751532 date "1992-05-01" @default.
- W2004751532 modified "2023-09-24" @default.
- W2004751532 title "In vivo gene amplification in non-cancerous cells: cholinesterase genes and oncogenes amplify in thrombocytopenia associated with lupus erythematosus" @default.
- W2004751532 cites W1947792159 @default.
- W2004751532 cites W1953332264 @default.
- W2004751532 cites W1977283045 @default.
- W2004751532 cites W1989187665 @default.
- W2004751532 cites W1995537903 @default.
- W2004751532 cites W2000754500 @default.
- W2004751532 cites W2022547352 @default.
- W2004751532 cites W2024800238 @default.
- W2004751532 cites W2033134260 @default.
- W2004751532 cites W2043981919 @default.
- W2004751532 cites W2044059781 @default.
- W2004751532 cites W2051013729 @default.
- W2004751532 cites W2071785245 @default.
- W2004751532 cites W2074043238 @default.
- W2004751532 cites W2117518758 @default.
- W2004751532 cites W2146203649 @default.
- W2004751532 cites W2262579606 @default.
- W2004751532 cites W2441594726 @default.
- W2004751532 cites W3025098425 @default.
- W2004751532 doi "https://doi.org/10.1016/0165-1110(92)90013-y" @default.
- W2004751532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1374519" @default.
- W2004751532 hasPublicationYear "1992" @default.
- W2004751532 type Work @default.
- W2004751532 sameAs 2004751532 @default.
- W2004751532 citedByCount "24" @default.
- W2004751532 countsByYear W20047515322013 @default.
- W2004751532 crossrefType "journal-article" @default.
- W2004751532 hasAuthorship W2004751532A5003680413 @default.
- W2004751532 hasAuthorship W2004751532A5045895671 @default.
- W2004751532 hasAuthorship W2004751532A5051208725 @default.
- W2004751532 hasAuthorship W2004751532A5075251637 @default.
- W2004751532 hasAuthorship W2004751532A5076319918 @default.
- W2004751532 hasConcept C104317684 @default.
- W2004751532 hasConcept C109159458 @default.
- W2004751532 hasConcept C134018914 @default.
- W2004751532 hasConcept C181199279 @default.
- W2004751532 hasConcept C203014093 @default.
- W2004751532 hasConcept C2778816929 @default.
- W2004751532 hasConcept C2779059548 @default.
- W2004751532 hasConcept C2779101902 @default.
- W2004751532 hasConcept C28328180 @default.
- W2004751532 hasConcept C31896038 @default.
- W2004751532 hasConcept C54355233 @default.
- W2004751532 hasConcept C55493867 @default.
- W2004751532 hasConcept C86803240 @default.
- W2004751532 hasConceptScore W2004751532C104317684 @default.
- W2004751532 hasConceptScore W2004751532C109159458 @default.
- W2004751532 hasConceptScore W2004751532C134018914 @default.
- W2004751532 hasConceptScore W2004751532C181199279 @default.
- W2004751532 hasConceptScore W2004751532C203014093 @default.
- W2004751532 hasConceptScore W2004751532C2778816929 @default.
- W2004751532 hasConceptScore W2004751532C2779059548 @default.
- W2004751532 hasConceptScore W2004751532C2779101902 @default.
- W2004751532 hasConceptScore W2004751532C28328180 @default.
- W2004751532 hasConceptScore W2004751532C31896038 @default.
- W2004751532 hasConceptScore W2004751532C54355233 @default.
- W2004751532 hasConceptScore W2004751532C55493867 @default.
- W2004751532 hasConceptScore W2004751532C86803240 @default.
- W2004751532 hasIssue "3" @default.
- W2004751532 hasLocation W20047515321 @default.
- W2004751532 hasLocation W20047515322 @default.
- W2004751532 hasOpenAccess W2004751532 @default.
- W2004751532 hasPrimaryLocation W20047515321 @default.
- W2004751532 hasRelatedWork W1952697976 @default.
- W2004751532 hasRelatedWork W1979437558 @default.
- W2004751532 hasRelatedWork W2011290762 @default.
- W2004751532 hasRelatedWork W2024692188 @default.
- W2004751532 hasRelatedWork W2043596173 @default.
- W2004751532 hasRelatedWork W2048736123 @default.
- W2004751532 hasRelatedWork W2346553461 @default.
- W2004751532 hasRelatedWork W2444018620 @default.
- W2004751532 hasRelatedWork W2950212861 @default.
- W2004751532 hasRelatedWork W4283725368 @default.
- W2004751532 hasVolume "276" @default.
- W2004751532 isParatext "false" @default.
- W2004751532 isRetracted "false" @default.
- W2004751532 magId "2004751532" @default.
- W2004751532 workType "article" @default.