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- W2004752457 abstract "Sleep disturbances often occur in association with psychiatric diseases, especially with depression. It is hypothesized that stress-activated HPA-axis (stimulated serial release of CRH, ACTH, and glucocorticoids) would be responsible for the symptoms, since exogenous administrations of CRH and its receptor antagonists are capable of modulating sleep. However, it is not fully determined how the CRH system is involved in developing sleep disorders, either at the level of releasing sites or receptor sites. To study on such mechanism, conventionally gene-ablated or knocked-in CRH models were used in the past. So far, CRH receptor type 1 knock-out (CRHR1 KO) mice failed to show any significant changes in sleep-wake behavior, whereas existing CRH overexpressing (OE) mice could not really endure sleep recordings because of their heavy sickness (Cushing's syndrome). Recently in our institute, three lines of brain structure-specific CRH-OE mice were generated: CNS-specific CRH-OENes mice, forebrain-specific CRH-OECam mice, and CRH neuron-specific COR26-Dlx mice. All our site-specific CRH-OE mice are healthy, and their HPA system stays intact. On the symposium, I am going to present their spontaneous sleep-wake activity. Further, sleep alternation occurring after sleep deprivation will be also compared. In these models, we have found significant differences in sleep patterns, especially in REM sleep, but no particular insomniac patterns. Altered sleep in CRH-OE mice can be normalized by treatment with a CRHR1 antagonist. According to the results obtained from our conditional CRH-OE mice, I would like to discuss the role of CRH in sleep-wake regulation and an involvement of CRH in sleep disorders." @default.
- W2004752457 created "2016-06-24" @default.
- W2004752457 creator A5064857788 @default.
- W2004752457 date "2007-09-10" @default.
- W2004752457 modified "2023-10-18" @default.
- W2004752457 title "Role of CRH in stress-related sleep disturbances: a study using site-specific CRH overexpressing mice" @default.
- W2004752457 doi "https://doi.org/10.1055/s-2007-990409" @default.
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