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• W2004753359 endingPage "809" @default.
• W2004753359 startingPage "796" @default.
• W2004753359 abstract "Abstract How plants adapt to low temperature is not well understood. To identify components involved in low-temperature signaling, we characterized the previously isolated chilling-sensitive2 mutant (chs2) of Arabidopsis (Arabidopsis thaliana). This mutant grew normally at 22°C but showed phenotypes similar to activation of defense responses when shifted to temperatures below 16°C. These phenotypes include yellowish and collapsed leaves, increased electrolyte leakage, up-regulation of PATHOGENESIS RELATED genes, and accumulation of excess hydrogen peroxide and salicylic acid (SA). Moreover, the chs2 mutant was seedling lethal when germinated at or shifted for more than 3 d to low temperatures of 4°C to 12°C. Map-based cloning revealed that a single amino acid substitution occurred in the TIR-NB-LRR (for Toll/Interleukin-1 receptor- nucleotide-binding Leucine-rich repeat)-type resistance (R) protein RPP4 (for Recognition of Peronospora parasitica4), which causes a deregulation of the R protein in a temperature-dependent manner. The chs2 mutation led to an increase in the mutated RPP4 mRNA transcript, activation of defense responses, and an induction of cell death at low temperatures. In addition, a chs2 intragenic suppressor, in which the mutation occurs in the conserved NB domain, abolished defense responses at lower temperatures. Genetic analyses of chs2 in combination with known SA pathway and immune signaling mutants indicate that the chs2-conferred temperature sensitivity requires ENHANCED DISEASE SUSCEPTIBILITY1, REQUIRED FOR Mla12 RESISTANCE, and SUPPRESSOR OF G2 ALLELE OF skp1 but does not require PHYTOALEXIN DEFICIENT4, NONEXPRESSOR OF PR GENES1, or SA. This study reveals that an activated TIR-NB-LRR protein has a large impact on temperature sensitivity in plant growth and survival." @default.
• W2004753359 created "2016-06-24" @default.
• W2004753359 creator A5011499963 @default.
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• W2004753359 creator A5040795581 @default.
• W2004753359 creator A5049849594 @default.
• W2004753359 creator A5055702128 @default.
• W2004753359 date "2010-08-10" @default.
• W2004753359 modified "2023-10-16" @default.
• W2004753359 title "A Gain-of-Function Mutation in the Arabidopsis Disease Resistance GeneRPP4Confers Sensitivity to Low Temperature" @default.
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• W2004753359 doi "https://doi.org/10.1104/pp.110.157610" @default.
• W2004753359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2949010" @default.
• W2004753359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20699401" @default.
• W2004753359 hasPublicationYear "2010" @default.
• W2004753359 type Work @default.
• W2004753359 sameAs 2004753359 @default.

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