Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004753389> ?p ?o ?g. }
- W2004753389 endingPage "190" @default.
- W2004753389 startingPage "181" @default.
- W2004753389 abstract "The olfactory bulb is located at the start of a hierarchical chain of sensory processing mechanisms. The relative ease of its isolation allows the possibility that models of these mechanisms might be integrated to develop a detailed understanding of function. In this sensory processing chain odour molecules evoke signal transduction in the olfactory receptor neurons. These signals represent the diverse range of molecular binding affinities of the olfactory receptor proteins. The first level of processing of this sensory input is performed by the neurons of the olfactory bulb. The olfactory system needs to filter the vast amount of sensory input it receives to be able to select the subset of biological significance. The importance of the olfactory bulb in this filtering process is suggested by its wide range of modulatory mechanisms. These mechanisms include an array of centrifugal inputs from other regions of the brain as well as numerous intrinsic feedback circuits. Given the complexity of the olfactory bulb and the range of its modulatory activity, the process of isolation of its components produces some difficulties of interpretation. This is mainly due to the removal of some of the effects of interaction and the change in balance that results. We present a summary of the current understanding of the interacting modulatory elements that are found in the olfactory bulb and a detailed account of the properties of mitral/tufted cells, the projection neurons of the olfactory bulb. This is followed by a discussion of the intrinsic and extrinsic modulatory systems acting on these cells. A consideration of the integration of the effects of these modulatory systems allows an understanding of how the output of the mitral/tufted cells is controlled. While significant progress has been made in the elucidation of the individual components as a result of advances in techniques over the last decade we suggest that there is a need for computational studies as a further aid to the understanding and interpretation of the weight of individual modulatory components in this dynamic interacting system. Keywords: Olfaction, olfactory bulb, granule cell, mitral cell, mitral/tufted cell, glomerulus, olfactory receptor neuron, olfactory neuron, oscillations" @default.
- W2004753389 created "2016-06-24" @default.
- W2004753389 creator A5059058378 @default.
- W2004753389 creator A5078909046 @default.
- W2004753389 date "2008-11-01" @default.
- W2004753389 modified "2023-09-25" @default.
- W2004753389 title "Neuropharmacology of the Olfactory Bulb" @default.
- W2004753389 cites W128191062 @default.
- W2004753389 cites W1484628435 @default.
- W2004753389 cites W1492144011 @default.
- W2004753389 cites W1494241005 @default.
- W2004753389 cites W1503677045 @default.
- W2004753389 cites W1508445445 @default.
- W2004753389 cites W1567258302 @default.
- W2004753389 cites W1567345817 @default.
- W2004753389 cites W1598291226 @default.
- W2004753389 cites W1659787745 @default.
- W2004753389 cites W1677270978 @default.
- W2004753389 cites W1726142052 @default.
- W2004753389 cites W1768602584 @default.
- W2004753389 cites W1776441027 @default.
- W2004753389 cites W1921967498 @default.
- W2004753389 cites W1967916519 @default.
- W2004753389 cites W1972897224 @default.
- W2004753389 cites W1973042031 @default.
- W2004753389 cites W1975270967 @default.
- W2004753389 cites W1982427791 @default.
- W2004753389 cites W1983217609 @default.
- W2004753389 cites W1984508253 @default.
- W2004753389 cites W1989597268 @default.
- W2004753389 cites W1989915533 @default.
- W2004753389 cites W1992901946 @default.
- W2004753389 cites W1997527085 @default.
- W2004753389 cites W1997681902 @default.
- W2004753389 cites W1998274485 @default.
- W2004753389 cites W1999062247 @default.
- W2004753389 cites W2000908815 @default.
- W2004753389 cites W2001247348 @default.
- W2004753389 cites W2001383967 @default.
- W2004753389 cites W2002032433 @default.
- W2004753389 cites W2003748551 @default.
- W2004753389 cites W2005382271 @default.
- W2004753389 cites W2007786915 @default.
- W2004753389 cites W2011325797 @default.
- W2004753389 cites W2011839234 @default.
- W2004753389 cites W2013593551 @default.
- W2004753389 cites W2015071500 @default.
- W2004753389 cites W2015657287 @default.
- W2004753389 cites W2017073487 @default.
- W2004753389 cites W2019939667 @default.
- W2004753389 cites W2020180904 @default.
- W2004753389 cites W2021333128 @default.
- W2004753389 cites W2021580070 @default.
- W2004753389 cites W2021732637 @default.
- W2004753389 cites W2022265329 @default.
- W2004753389 cites W2024738702 @default.
- W2004753389 cites W2024806933 @default.
- W2004753389 cites W2029080005 @default.
- W2004753389 cites W2033814633 @default.
- W2004753389 cites W2035817750 @default.
- W2004753389 cites W2038576244 @default.
- W2004753389 cites W2039683761 @default.
- W2004753389 cites W2041492540 @default.
- W2004753389 cites W2041806773 @default.
- W2004753389 cites W2047613989 @default.
- W2004753389 cites W2049490437 @default.
- W2004753389 cites W2050465153 @default.
- W2004753389 cites W2052293800 @default.
- W2004753389 cites W2053210925 @default.
- W2004753389 cites W2056436013 @default.
- W2004753389 cites W2061949345 @default.
- W2004753389 cites W2062310763 @default.
- W2004753389 cites W2064551824 @default.
- W2004753389 cites W2065549819 @default.
- W2004753389 cites W2068083086 @default.
- W2004753389 cites W2071782304 @default.
- W2004753389 cites W2071966958 @default.
- W2004753389 cites W2073037073 @default.
- W2004753389 cites W2073399843 @default.
- W2004753389 cites W2073546303 @default.
- W2004753389 cites W2074883704 @default.
- W2004753389 cites W2075750051 @default.
- W2004753389 cites W2076583332 @default.
- W2004753389 cites W2077778849 @default.
- W2004753389 cites W2077838565 @default.
- W2004753389 cites W2079039836 @default.
- W2004753389 cites W2079864604 @default.
- W2004753389 cites W2081246158 @default.
- W2004753389 cites W2082782774 @default.
- W2004753389 cites W2084318262 @default.
- W2004753389 cites W2086724428 @default.
- W2004753389 cites W2088189758 @default.
- W2004753389 cites W2091828531 @default.
- W2004753389 cites W2096709273 @default.
- W2004753389 cites W2096801369 @default.
- W2004753389 cites W2105888718 @default.
- W2004753389 cites W2107943317 @default.
- W2004753389 cites W2125086983 @default.