FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004753625> ?p ?o ?g. }

• W2004753625 endingPage "799" @default.
• W2004753625 startingPage "792" @default.
• W2004753625 abstract "Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier protein family that are present in the mitochondrial inner membrane and mediate free fatty acid (FFA)-activated, purine nucleotide (PN)-inhibited proton conductance. Since 1999, the presence of UCPs has been demonstrated in some non-photosynthesising unicellular eukaryotes, including amoeboid and parasite protists, as well as in non-fermentative yeast and filamentous fungi. In the mitochondria of these organisms, UCP activity is revealed upon FFA-induced, PN-inhibited stimulation of resting respiration and a decrease in membrane potential, which are accompanied by a decrease in membranous ubiquinone (Q) reduction level. UCPs in unicellular eukaryotes are able to divert energy from oxidative phosphorylation and thus compete for a proton electrochemical gradient with ATP synthase. Our recent work indicates that membranous Q is a metabolic sensor that might utilise its redox state to release the PN inhibition of UCP-mediated mitochondrial uncoupling under conditions of phosphorylation and resting respiration. The action of reduced Q (QH2) could allow higher or complete activation of UCP. As this regulatory feature was demonstrated for microorganism UCPs (A. castellanii UCP), plant and mammalian UCP1 analogues, and UCP1 in brown adipose tissue, the process could involve all UCPs. Here, we discuss the functional connection and physiological role of UCP and alternative oxidase, two main energy-dissipating systems in the plant-type mitochondrial respiratory chain of unicellular eukaryotes, including the control of cellular energy balance as well as preventive action against the production of reactive oxygen species." @default.
• W2004753625 created "2016-06-24" @default.
• W2004753625 creator A5030681870 @default.
• W2004753625 creator A5053871532 @default.
• W2004753625 creator A5089966506 @default.
• W2004753625 creator A5091145817 @default.
• W2004753625 date "2010-06-01" @default.
• W2004753625 modified "2023-10-18" @default.
• W2004753625 title "Mitochondrial uncoupling proteins in unicellular eukaryotes" @default.
• W2004753625 cites W1530102586 @default.
• W2004753625 cites W1925374247 @default.
• W2004753625 cites W1972225104 @default.
• W2004753625 cites W1976873132 @default.
• W2004753625 cites W1982377654 @default.
• W2004753625 cites W1984287317 @default.
• W2004753625 cites W1987981231 @default.
• W2004753625 cites W1992485652 @default.
• W2004753625 cites W1996319270 @default.
• W2004753625 cites W1996659589 @default.
• W2004753625 cites W1997432335 @default.
• W2004753625 cites W1997801607 @default.
• W2004753625 cites W1999159221 @default.
• W2004753625 cites W1999979388 @default.
• W2004753625 cites W2000588392 @default.
• W2004753625 cites W2002125583 @default.
• W2004753625 cites W2003371798 @default.
• W2004753625 cites W2004030064 @default.
• W2004753625 cites W2015936278 @default.
• W2004753625 cites W2018906617 @default.
• W2004753625 cites W2019877384 @default.
• W2004753625 cites W2020410746 @default.
• W2004753625 cites W2021795499 @default.
• W2004753625 cites W2025093005 @default.
• W2004753625 cites W2025259609 @default.
• W2004753625 cites W2025279251 @default.
• W2004753625 cites W2026900534 @default.
• W2004753625 cites W2032693257 @default.
• W2004753625 cites W2036573181 @default.
• W2004753625 cites W2036685072 @default.
• W2004753625 cites W2043585539 @default.
• W2004753625 cites W2043848725 @default.
• W2004753625 cites W2052234833 @default.
• W2004753625 cites W2053273700 @default.
• W2004753625 cites W2054383249 @default.
• W2004753625 cites W2054770604 @default.
• W2004753625 cites W2056752315 @default.
• W2004753625 cites W2058838030 @default.
• W2004753625 cites W2060772604 @default.
• W2004753625 cites W2061582583 @default.
• W2004753625 cites W2073912029 @default.
• W2004753625 cites W2074033606 @default.
• W2004753625 cites W2077137089 @default.
• W2004753625 cites W2082883974 @default.
• W2004753625 cites W2086198406 @default.
• W2004753625 cites W2087210158 @default.
• W2004753625 cites W2090738842 @default.
• W2004753625 cites W2093272452 @default.
• W2004753625 cites W2100151397 @default.
• W2004753625 cites W2104253996 @default.
• W2004753625 cites W2107726656 @default.
• W2004753625 cites W2109814527 @default.
• W2004753625 cites W2122649165 @default.
• W2004753625 cites W2124724505 @default.
• W2004753625 cites W2128277472 @default.
• W2004753625 cites W2133609778 @default.
• W2004753625 cites W2134411467 @default.
• W2004753625 cites W2136689463 @default.
• W2004753625 cites W2141950542 @default.
• W2004753625 cites W2142048738 @default.
• W2004753625 cites W2156257778 @default.
• W2004753625 cites W2158591483 @default.
• W2004753625 cites W2161094568 @default.
• W2004753625 cites W2163173378 @default.
• W2004753625 cites W3104308126 @default.
• W2004753625 cites W4242123597 @default.
• W2004753625 cites W76885403 @default.
• W2004753625 doi "https://doi.org/10.1016/j.bbabio.2009.12.005" @default.
• W2004753625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20026010" @default.
• W2004753625 hasPublicationYear "2010" @default.
• W2004753625 type Work @default.
• W2004753625 sameAs 2004753625 @default.
• W2004753625 citedByCount "44" @default.
• W2004753625 countsByYear W20047536252012 @default.
• W2004753625 countsByYear W20047536252013 @default.
• W2004753625 countsByYear W20047536252014 @default.
• W2004753625 countsByYear W20047536252015 @default.
• W2004753625 countsByYear W20047536252016 @default.
• W2004753625 countsByYear W20047536252017 @default.
• W2004753625 countsByYear W20047536252019 @default.
• W2004753625 countsByYear W20047536252020 @default.
• W2004753625 countsByYear W20047536252021 @default.
• W2004753625 countsByYear W20047536252022 @default.
• W2004753625 countsByYear W20047536252023 @default.
• W2004753625 crossrefType "journal-article" @default.
• W2004753625 hasAuthorship W2004753625A5030681870 @default.
• W2004753625 hasAuthorship W2004753625A5053871532 @default.
• W2004753625 hasAuthorship W2004753625A5089966506 @default.
• W2004753625 hasAuthorship W2004753625A5091145817 @default.

• next