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- W2004753631 abstract "Functionality of the endogenous cannabinoid system undergoes relevant changes in reward-related brain areas in animal models of opiate addiction. By using a limited access heroin self-administration paradigm we show that cannabinoid CB(1) receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride (SR141716A, 0.03-3.0 mg/kg) suppresses heroin self-administration only in opiate-dependent rats but not in non-dependent animals. These results further support the study of cannabinoid CB(1) receptor antagonists for the treatment of opiate addiction." @default.
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- W2004753631 date "2004-10-01" @default.
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- W2004753631 title "Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats" @default.
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- W2004753631 doi "https://doi.org/10.1016/j.ejphar.2004.08.022" @default.
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