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• W2004754456 abstract "Both thymocytes and tumor cells express M2 type isoenzyme of pyruvate kinase (M2PK), which is different from R type isoenzyme of pyruvate kinase (RPK) that is expressed in erythrocytes. In this report, the effect of RPK and M2PK on the transcription of human immunodeficiency virus type 1 (HIV-1) was tested. The results indicated that M2PK could enhance HIV-1 transcription from its long terminal repeat (LTR) promoter, while RPK did not have such an effect. Specific down-regulation of M2PK could inhibit HIV-1 transcription from its LTR region. Furthermore, it was found that the C terminal region of M2PK is responsible for this effect. Collectively, the cellular factor M2PK that is expressed in thymocytes could facilitate the transcription of HIV-1." @default.
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• W2004754456 date "2010-01-05" @default.
• W2004754456 modified "2023-09-28" @default.
• W2004754456 title "M2 pyruvate kinase enhances HIV-1 transcription from its long terminal repeat" @default.
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• W2004754456 doi "https://doi.org/10.1007/s11515-010-0005-x" @default.
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