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• W2004755165 abstract "Activation of the endothelium plays an important role in the innate immune response. This process is associated with an increase in the production of superoxide (O2−) by nicotinamide adenine dinucleotide phosphate (reduced form; NADPH) oxidase. Our objective was to determine if O2− from NADPH oxidase contributes to activation of human umbilical vein endothelial cells by LPS as it does for TNF-α. We used the adhesion molecule intracellular adhesion molecule 1 and cytokine IL-8 as indicators of human umbilical vein endothelial cell activation and measured O2− production with chemiluminescence. LPS increased baseline and NADPH-stimulated O2− production. The increase was reduced by tiron, a protein kinase C inhibitor (bisindolylmaleimide I hydrochloride), the flavin inhibitor (diphenylene iodonium), and by a short interfering RNA against the p22phox component of NADPH oxidase. Inhibition of NADPH oxidase with the short interfering RNA reduced the induction by LPS of intracellular adhesion molecule 1 mRNA, protein, and IL-8 release (by enzyme-linked immunosorbent assay). The production of O2− by NADPH oxidase contributes to intracellular signaling by LPS in endothelial cells as it does for TNF-α and helps turn on the innate immune response in these cells. ABBREVIATIONS Lucigenin-Bis-N-methylacridinum nitrate; DPI-diphenylene iodonium; tiron-4,5-Dihydroxy-1, 3-benzene-disulfonic acid; HUVEC-human umbilical vein endothelial cells; ICAM-1-intercellular adhesion molecule type1; O2-superoxide" @default.
• W2004755165 created "2016-06-24" @default.
• W2004755165 creator A5042897529 @default.
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• W2004755165 date "2008-05-01" @default.
• W2004755165 modified "2023-09-26" @default.
• W2004755165 title "NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) OXIDASE IS IMPORTANT FOR LPS-INDUCED ENDOTHELIAL CELL ACTIVATION" @default.
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• W2004755165 doi "https://doi.org/10.1097/shk.0b013e318157ebc8" @default.
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