Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004755236> ?p ?o ?g. }
- W2004755236 endingPage "322" @default.
- W2004755236 startingPage "315" @default.
- W2004755236 abstract "The mechanisms by which nerve growth factor (NGF) induces thermal hyperalgesia and neutrophil accumulation have been investigated in the rat. Thermal nociceptive thresholds in rat hind paw were measured as the time taken for paw withdrawal from a heat source and neutrophil accumulation was measured in hind paw and dorsal skin samples using a myeloperoxidase assay. NGF (23–80 pmol intra-plantar (i.pl.) injection) induced a significant (P<0.05, n=6–16) thermal hyperalgesia at 5 h after injection and significant neutrophil accumulation (P<0.05, n=6) was observed with NGF (40 pmol). In dorsal skin, where multiple samples can be assessed, intradermal (i.d.) NGF was 10–30 times less potent than interleukin-1β in inducing neutrophil accumulation. The 5-lipoxygenase inhibitor ZM230487 (10 nmol co-injected with NGF) significantly attenuated neutrophil accumulation and hyperalgesia induced by NGF; unlike the histamine and 5-hydroxytryptamine antagonists (mepyramine and methysergide) which were without effect at the times measured. Furthermore, depletion of circulating neutrophils (using a rabbit anti-rat neutrophil antibody) abolished NGF induced hyperalgesia. These results indicate that neutrophils, which accumulate in response to a 5-lipoxygenase product, play a crucial role in NGF-induced hyperalgesia." @default.
- W2004755236 created "2016-06-24" @default.
- W2004755236 creator A5008228016 @default.
- W2004755236 creator A5054438337 @default.
- W2004755236 creator A5069263649 @default.
- W2004755236 creator A5081165735 @default.
- W2004755236 date "1998-09-01" @default.
- W2004755236 modified "2023-09-27" @default.
- W2004755236 title "Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils" @default.
- W2004755236 cites W1739697637 @default.
- W2004755236 cites W1754799414 @default.
- W2004755236 cites W1840804593 @default.
- W2004755236 cites W1943785082 @default.
- W2004755236 cites W1944875462 @default.
- W2004755236 cites W1965779217 @default.
- W2004755236 cites W1966612762 @default.
- W2004755236 cites W1968830866 @default.
- W2004755236 cites W1971455937 @default.
- W2004755236 cites W1978791534 @default.
- W2004755236 cites W1998395003 @default.
- W2004755236 cites W2000983477 @default.
- W2004755236 cites W2007990557 @default.
- W2004755236 cites W2010183804 @default.
- W2004755236 cites W2013288331 @default.
- W2004755236 cites W2014007136 @default.
- W2004755236 cites W2022031142 @default.
- W2004755236 cites W2022323320 @default.
- W2004755236 cites W2023664228 @default.
- W2004755236 cites W2027113170 @default.
- W2004755236 cites W2031647876 @default.
- W2004755236 cites W2043152772 @default.
- W2004755236 cites W2047553141 @default.
- W2004755236 cites W2050517668 @default.
- W2004755236 cites W2051140711 @default.
- W2004755236 cites W2066157045 @default.
- W2004755236 cites W2068591703 @default.
- W2004755236 cites W2069718130 @default.
- W2004755236 cites W2078634957 @default.
- W2004755236 cites W2079484889 @default.
- W2004755236 cites W2086811698 @default.
- W2004755236 cites W2095051237 @default.
- W2004755236 cites W2099173554 @default.
- W2004755236 cites W2117771600 @default.
- W2004755236 cites W2158159893 @default.
- W2004755236 cites W2413883001 @default.
- W2004755236 cites W2470632500 @default.
- W2004755236 doi "https://doi.org/10.1016/s0304-3959(98)00114-6" @default.
- W2004755236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9808357" @default.
- W2004755236 hasPublicationYear "1998" @default.
- W2004755236 type Work @default.
- W2004755236 sameAs 2004755236 @default.
- W2004755236 citedByCount "115" @default.
- W2004755236 countsByYear W20047552362012 @default.
- W2004755236 countsByYear W20047552362013 @default.
- W2004755236 countsByYear W20047552362014 @default.
- W2004755236 countsByYear W20047552362015 @default.
- W2004755236 countsByYear W20047552362016 @default.
- W2004755236 countsByYear W20047552362017 @default.
- W2004755236 countsByYear W20047552362018 @default.
- W2004755236 countsByYear W20047552362019 @default.
- W2004755236 countsByYear W20047552362020 @default.
- W2004755236 countsByYear W20047552362022 @default.
- W2004755236 countsByYear W20047552362023 @default.
- W2004755236 crossrefType "journal-article" @default.
- W2004755236 hasAuthorship W2004755236A5008228016 @default.
- W2004755236 hasAuthorship W2004755236A5054438337 @default.
- W2004755236 hasAuthorship W2004755236A5069263649 @default.
- W2004755236 hasAuthorship W2004755236A5081165735 @default.
- W2004755236 hasConcept C1122143 @default.
- W2004755236 hasConcept C126322002 @default.
- W2004755236 hasConcept C134018914 @default.
- W2004755236 hasConcept C15490471 @default.
- W2004755236 hasConcept C170493617 @default.
- W2004755236 hasConcept C185592680 @default.
- W2004755236 hasConcept C203014093 @default.
- W2004755236 hasConcept C203565725 @default.
- W2004755236 hasConcept C2775864247 @default.
- W2004755236 hasConcept C2776885963 @default.
- W2004755236 hasConcept C2776914184 @default.
- W2004755236 hasConcept C2778423431 @default.
- W2004755236 hasConcept C2778937273 @default.
- W2004755236 hasConcept C2779090179 @default.
- W2004755236 hasConcept C2779245659 @default.
- W2004755236 hasConcept C2781005078 @default.
- W2004755236 hasConcept C51738704 @default.
- W2004755236 hasConcept C55493867 @default.
- W2004755236 hasConcept C71924100 @default.
- W2004755236 hasConcept C98274493 @default.
- W2004755236 hasConceptScore W2004755236C1122143 @default.
- W2004755236 hasConceptScore W2004755236C126322002 @default.
- W2004755236 hasConceptScore W2004755236C134018914 @default.
- W2004755236 hasConceptScore W2004755236C15490471 @default.
- W2004755236 hasConceptScore W2004755236C170493617 @default.
- W2004755236 hasConceptScore W2004755236C185592680 @default.
- W2004755236 hasConceptScore W2004755236C203014093 @default.
- W2004755236 hasConceptScore W2004755236C203565725 @default.
- W2004755236 hasConceptScore W2004755236C2775864247 @default.
- W2004755236 hasConceptScore W2004755236C2776885963 @default.