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• W2004756130 abstract "Humour is a complex cognitive and emotional construct that is vulnerable in neurodegenerative diseases, notably the frontotemporal lobar degenerations. However, humour processing in these diseases has been little studied. Here we assessed humour processing in patients with behavioural variant frontotemporal dementia (n = 22, mean age 67 years, four female) and semantic dementia (n = 11, mean age 67 years, five female) relative to healthy individuals (n = 21, mean age 66 years, 11 female), using a joint cognitive and neuroanatomical approach. We created a novel neuropsychological test requiring a decision about the humorous intent of nonverbal cartoons, in which we manipulated orthogonally humour content and familiarity of depicted scenarios. Structural neuroanatomical correlates of humour detection were assessed using voxel-based morphometry. Assessing performance in a signal detection framework and after adjusting for standard measures of cognitive function, both patient groups showed impaired accuracy of humour detection in familiar and novel scenarios relative to healthy older controls (p < .001). Patient groups showed similar overall performance profiles; however the behavioural variant frontotemporal dementia group alone showed a significant advantage for detection of humour in familiar relative to novel scenarios (p = .045), suggesting that the behavioural variant syndrome may lead to particular difficulty decoding novel situations for humour, while semantic dementia produces a more general deficit of humour detection that extends to stock comedic situations. Humour detection accuracy was associated with grey matter volume in a distributed network including temporo-parietal junctional and anterior superior temporal cortices, with predominantly left-sided correlates of processing humour in familiar scenarios and right-sided correlates of processing novel humour. The findings quantify deficits of core cognitive operations underpinning humour processing in frontotemporal lobar degenerations and suggest a candidate brain substrate in cortical hub regions processing incongruity and semantic associations. Humour is a promising candidate tool with which to assess complex social signal processing in neurodegenerative disease." @default.
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• W2004756130 date "2015-08-01" @default.
• W2004756130 modified "2023-09-26" @default.
• W2004756130 title "Humour processing in frontotemporal lobar degeneration: A behavioural and neuroanatomical analysis" @default.
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• W2004756130 cites W1945878543 @default.
• W2004756130 cites W1952190660 @default.
• W2004756130 cites W1968133994 @default.
• W2004756130 cites W1972685664 @default.
• W2004756130 cites W1974043713 @default.
• W2004756130 cites W1977315588 @default.
• W2004756130 cites W1982023653 @default.
• W2004756130 cites W1984556426 @default.
• W2004756130 cites W1984846830 @default.
• W2004756130 cites W1986153996 @default.
• W2004756130 cites W1987259395 @default.
• W2004756130 cites W1996862751 @default.
• W2004756130 cites W2000721738 @default.
• W2004756130 cites W2008069933 @default.
• W2004756130 cites W2009204038 @default.
• W2004756130 cites W2011348380 @default.
• W2004756130 cites W2014782786 @default.
• W2004756130 cites W2015185149 @default.
• W2004756130 cites W2015425485 @default.
• W2004756130 cites W2019348613 @default.
• W2004756130 cites W2026509183 @default.
• W2004756130 cites W2027067157 @default.
• W2004756130 cites W2028737230 @default.
• W2004756130 cites W2030645300 @default.
• W2004756130 cites W2030761935 @default.
• W2004756130 cites W2035110209 @default.
• W2004756130 cites W2042921760 @default.
• W2004756130 cites W2044311153 @default.
• W2004756130 cites W2044755068 @default.
• W2004756130 cites W2049797561 @default.
• W2004756130 cites W2056658203 @default.
• W2004756130 cites W2068944434 @default.
• W2004756130 cites W2072435870 @default.
• W2004756130 cites W2076587477 @default.
• W2004756130 cites W2078901468 @default.
• W2004756130 cites W2080816290 @default.
• W2004756130 cites W2083193074 @default.
• W2004756130 cites W2083635328 @default.
• W2004756130 cites W2086535807 @default.
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• W2004756130 cites W2138190873 @default.
• W2004756130 cites W2139210237 @default.
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• W2004756130 doi "https://doi.org/10.1016/j.cortex.2015.03.024" @default.
• W2004756130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4534772" @default.
• W2004756130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25973788" @default.
• W2004756130 hasPublicationYear "2015" @default.
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