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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004757564> ?p ?o ?g. }

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• W2004757564 abstract "To clarify the mechanism of eosinophilia in adult T-cell leukemia (ATL), we studied three ATL patients having marked eosinophilia. Eosinophil-predominant colony-stimulating activity was detected in the serum of one patient and in the conditioned media (CM) from cultured ATL cells from two patients. Soluble interleukin 5 (IL-5), but no interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF), was detected in sera from all patients. On the other hand, GM-CSF was produced in vitro by ATL cells from all cases, whereas detectable IL-3 and IL-5 was produced by cells from only one, suggesting that in the other two cases, the serum IL-5 was produced by the normal reacting lymphocytes. The fact that no patient showed marked neutrophilia supports the possibility that IL-5 may have a leading role in the development of eosinophilia, with GM-CSF produced by ATL cells playing a complementary role." @default.
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• W2004757564 date "1998-11-01" @default.
• W2004757564 modified "2023-09-25" @default.
• W2004757564 title "Eosinophilia associated with adult t-cell leukemia: Role of interleukin 5 and granulocyte-macrophage colony-stimulating factor" @default.
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• W2004757564 doi "https://doi.org/10.1002/(sici)1096-8652(199811)59:3<242::aid-ajh11>3.0.co;2-o" @default.
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