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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004758287> ?p ?o ?g. }

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• W2004758287 abstract "Valienamine analogues having alpha- and beta-galactose-type structures were synthesized by racemic modification from (1SR,2RS,3SR)-6-methylenecyclohex-4-ene-1,2,3-triol. Four N-alkyl derivatives of the beta-anomer were readily prepared selectively by treatment of key intermediate 2,6-di-O-acetyl-3,4-O-isopropylidene-5a-carba-alpha- and beta-l-arabino-hex-5(5a)-enopyranosyl bromides with alkyl amines. All compounds were assayed for inhibitory activity against six glycosidases, and the N-dodecyl derivative was shown to be a very strong inhibitor of beta-galactosidase (IC(50) 0.01 microM, bovine liver)." @default.
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• W2004758287 date "2004-03-01" @default.
• W2004758287 modified "2023-10-17" @default.
• W2004758287 title "Convenient synthesis and evaluation of glycosidase inhibitory activity of α- and β-galactose-type valienamines, and some N -alkyl derivatives" @default.
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• W2004758287 doi "https://doi.org/10.1016/j.bmc.2003.12.016" @default.
• W2004758287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14980612" @default.
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