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- W2004758301 abstract "The rate of disappearance from plasma and tissue localization of radioactivity were determined in rabbits following intravenous injections of radioiodinated human growth hormone (HGH*), and radioiodinated human serum albumin (HSA*). Tissue localization of radioactivity after Nal131 injection was also examined. HGH* was quickly cleared from the blood; during the extremely rapid initial period (between 2 and 10 minutes), the concentration of trichloroacetic acid precipitable plasma radioactivity fell by 61 %. For the interval 10 to 60 minutes, mean half-time of disappearance of 17.6 ±1.8 minutes (standard error) was determined in a group of 11 rabbits. Half-time of disappearance did not differ in young as compared with old animals. Listed in decreasing order, the tissue radioactivity concentrations at 90 minutes were: kidney, liver, lung, spleen, skin, adrenal, testis, intestine, marrow, pancreas, skeletal muscle fat and cerebral cortex. Substantial proportions of the radioactivity found in the liver and ki..." @default.
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- W2004758301 date "1962-04-01" @default.
- W2004758301 modified "2023-09-27" @default.
- W2004758301 title "The Fate of I131-Labeled Human Growth Hormone in the Rabbit" @default.
- W2004758301 doi "https://doi.org/10.1210/endo-70-4-459" @default.
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