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• W2004758829 abstract "G350 of Escherichia coli RNase P RNA is a highly conserved residue among all bacteria and lies near the known magnesium binding site for the RNase P ribozyme, helix P4. Mutations at G350 have a dramatic effect on substrate cleavage activity for both RNA alone and holoenzyme; the G350C mutation has the most severe phenotype. The G350C mutation also inhibits growth of cells that express the mutant RNA in vivo under conditions of magnesium starvation. The results suggest that G350 contributes to Mg(2+) binding at helix P4 of RNase P RNA." @default.
• W2004758829 created "2016-06-24" @default.
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• W2004758829 date "2002-07-01" @default.
• W2004758829 modified "2023-10-16" @default.
• W2004758829 title "G350 of Escherichia coli RNase P RNA contributes to Mg 2+ binding near the active site of the enzyme" @default.
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• W2004758829 doi "https://doi.org/10.1016/s0378-1119(02)00766-7" @default.
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