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• W2004758839 abstract "We previously reported that Sp1-dependent Cdc2 gene expression is inhibited by tetra- O -methyl nordihydroguaiaretic acid (M 4 N) and that M 4 N is likely responsible for causing growth arrest in M 4 N-treated transformed C3 cells. Here, we show that after M 4 N treatment and cell-cycle arrest, expression of the Sp1-dependent survivin gene, a member of the inhibitor of apoptosis family, is also suppressed, and the mitochondrial apoptotic pathway is activated. To confirm that inhibition of Cdc2 and survivin gene expression is necessary for M 4 N-induced growth arrest and apoptosis, we tested the effect of adding Cdc2 and survivin back to M 4 N-treated cells. Cell division was transiently restored in the presence of M 4 N after transfection of an exogenous Cdc2 gene copy under the control of the Sp1-independent cytomegalovirus promoter. Caspase-3 activation was also reduced by 50% and 75% in transiently and stably survivin-transfected C3 cells, respectively. The results suggest that M 4 N induces growth arrest and apoptosis by suppressing Cdc2 and survivin expression, which constitutes the cellular basis of its antitumoric action." @default.
• W2004758839 created "2016-06-24" @default.
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• W2004758839 date "2004-08-25" @default.
• W2004758839 modified "2023-10-18" @default.
• W2004758839 title "Tetra- <i>O</i> -methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression" @default.
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• W2004758839 doi "https://doi.org/10.1073/pnas.0405407101" @default.
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