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• W2004759145 abstract "In pneumonia caused by the bacterium <b>Staphylococcus aureus</b>, the intense inflammatory response that is triggered by this infection can lead to the development of lung injury. Little is known, however, about the impact of specific virulence factors on this inflammatory disorder, which causes both significant mortality and morbidity. In this study, we examined the role of β-toxin, a neutral sphingomyelinase, in <b>S. aureus</b>-induced lung injury. Our results showed that the central features of lung injury—specifically, increased neutrophilic inflammation, vascular leakage of serum proteins into the lung tissue, and exudation of proteins into the airway—are significantly attenuated in mice infected intranasally with <b>S. aureus</b> deficient in β-toxin compared with mice infected with <b>S. aureus</b> expressing β-toxin. In addition, intranasal administration of β-toxin evoked the characteristic features of lung injury in wild-type mice whereas neutropenic mice were protected from such injury. However, mutant β-toxin mice deficient in sphingomyelinase activity failed to trigger features of lung injury. Ablation of sphingomyelinase activity also interfered with the ability of β-toxin to stimulate ectodomain shedding of syndecan-1, a major heparan sulfate proteoglycan found in epithelial cells. Moreover, syndecan-1-null mice were significantly protected from β-toxin-induced lung injury relative to wild-type mice. These data indicate that <b>S. aureus</b> β-toxin is a critical virulence factor that induces neutrophil-mediated lung injury through both its sphingomyelinase activity and syndecan-1." @default.
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• W2004759145 date "2009-02-01" @default.
• W2004759145 modified "2023-10-18" @default.
• W2004759145 title "Staphylococcus aureus Beta-Toxin Induces Lung Injury through Syndecan-1" @default.
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• W2004759145 doi "https://doi.org/10.2353/ajpath.2009.080394" @default.
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