Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004768456> ?p ?o ?g. }
- W2004768456 endingPage "139" @default.
- W2004768456 startingPage "132" @default.
- W2004768456 abstract "Glial cell line-derived neurotrophic factor (GDNF) family ligands are target-derived trophic factors for several neuronal subpopulations. They promote survival and neurite outgrowth through binding to specific members of the GDNF family receptor alpha (GFR alpha) and subsequent activation of the RET tyrosine kinase receptor. Using compartmentalized cultures of sympathetic neurons, we have studied the mechanism of GDNF retrograde signaling. Our results demonstrate the presence of GDNF receptors RET and GFR alpha 1 in the two cellular compartments, cell bodies and distal axons. Addition of GDNF to either compartment initiated local signaling, including activation of RET and its downstream effectors AKT and ERK1/2. Addition of GDNF to distal axons induced a retrograde signal leading to neuronal survival and neurite outgrowth. Retrograde signaling was associated with retrograde transport of radiolabeled GDNF and GFR alpha 1, as well as activation of RET and AKT, but not of ERK1/2, in cell bodies. No anterograde signal propagation or transport was observed. Our results suggest a general mechanism for retrograde signaling initiated at distal axons through tyrosine kinase receptors." @default.
- W2004768456 created "2016-06-24" @default.
- W2004768456 creator A5055040328 @default.
- W2004768456 creator A5080792840 @default.
- W2004768456 date "2004-10-01" @default.
- W2004768456 modified "2023-10-02" @default.
- W2004768456 title "Retrograde propagation of GDNF-mediated signals in sympathetic neurons" @default.
- W2004768456 cites W1590041608 @default.
- W2004768456 cites W1600856176 @default.
- W2004768456 cites W1917948692 @default.
- W2004768456 cites W1931706129 @default.
- W2004768456 cites W1971208141 @default.
- W2004768456 cites W1981260497 @default.
- W2004768456 cites W1981464105 @default.
- W2004768456 cites W1986538583 @default.
- W2004768456 cites W1989381407 @default.
- W2004768456 cites W1994716213 @default.
- W2004768456 cites W1996246254 @default.
- W2004768456 cites W2009259931 @default.
- W2004768456 cites W2011381918 @default.
- W2004768456 cites W2017179344 @default.
- W2004768456 cites W2019843044 @default.
- W2004768456 cites W2020333978 @default.
- W2004768456 cites W2022730960 @default.
- W2004768456 cites W2029725727 @default.
- W2004768456 cites W2051455449 @default.
- W2004768456 cites W2052659902 @default.
- W2004768456 cites W2052938035 @default.
- W2004768456 cites W2055804358 @default.
- W2004768456 cites W2061071032 @default.
- W2004768456 cites W2063103796 @default.
- W2004768456 cites W2063695629 @default.
- W2004768456 cites W2069482942 @default.
- W2004768456 cites W2070782703 @default.
- W2004768456 cites W2084641355 @default.
- W2004768456 cites W2087410257 @default.
- W2004768456 cites W2088195185 @default.
- W2004768456 cites W2088885861 @default.
- W2004768456 cites W2090061589 @default.
- W2004768456 cites W2103913070 @default.
- W2004768456 cites W2106765135 @default.
- W2004768456 cites W2110140150 @default.
- W2004768456 cites W2110682302 @default.
- W2004768456 cites W2118568266 @default.
- W2004768456 cites W2122082144 @default.
- W2004768456 cites W2124386542 @default.
- W2004768456 cites W2125384746 @default.
- W2004768456 cites W2131711809 @default.
- W2004768456 cites W2135776211 @default.
- W2004768456 cites W2139696718 @default.
- W2004768456 cites W2144178897 @default.
- W2004768456 cites W2155519338 @default.
- W2004768456 cites W2159097181 @default.
- W2004768456 cites W2167423680 @default.
- W2004768456 cites W2170416930 @default.
- W2004768456 doi "https://doi.org/10.1016/j.mcn.2004.06.001" @default.
- W2004768456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15485769" @default.
- W2004768456 hasPublicationYear "2004" @default.
- W2004768456 type Work @default.
- W2004768456 sameAs 2004768456 @default.
- W2004768456 citedByCount "42" @default.
- W2004768456 countsByYear W20047684562012 @default.
- W2004768456 countsByYear W20047684562014 @default.
- W2004768456 countsByYear W20047684562015 @default.
- W2004768456 countsByYear W20047684562016 @default.
- W2004768456 countsByYear W20047684562017 @default.
- W2004768456 countsByYear W20047684562018 @default.
- W2004768456 countsByYear W20047684562019 @default.
- W2004768456 countsByYear W20047684562021 @default.
- W2004768456 countsByYear W20047684562023 @default.
- W2004768456 crossrefType "journal-article" @default.
- W2004768456 hasAuthorship W2004768456A5055040328 @default.
- W2004768456 hasAuthorship W2004768456A5080792840 @default.
- W2004768456 hasConcept C101544691 @default.
- W2004768456 hasConcept C113246987 @default.
- W2004768456 hasConcept C160539049 @default.
- W2004768456 hasConcept C169760540 @default.
- W2004768456 hasConcept C170493617 @default.
- W2004768456 hasConcept C185856081 @default.
- W2004768456 hasConcept C202751555 @default.
- W2004768456 hasConcept C2908751931 @default.
- W2004768456 hasConcept C55493867 @default.
- W2004768456 hasConcept C62478195 @default.
- W2004768456 hasConcept C70192387 @default.
- W2004768456 hasConcept C75217442 @default.
- W2004768456 hasConcept C86803240 @default.
- W2004768456 hasConcept C94296188 @default.
- W2004768456 hasConcept C95444343 @default.
- W2004768456 hasConceptScore W2004768456C101544691 @default.
- W2004768456 hasConceptScore W2004768456C113246987 @default.
- W2004768456 hasConceptScore W2004768456C160539049 @default.
- W2004768456 hasConceptScore W2004768456C169760540 @default.
- W2004768456 hasConceptScore W2004768456C170493617 @default.
- W2004768456 hasConceptScore W2004768456C185856081 @default.
- W2004768456 hasConceptScore W2004768456C202751555 @default.
- W2004768456 hasConceptScore W2004768456C2908751931 @default.
- W2004768456 hasConceptScore W2004768456C55493867 @default.
- W2004768456 hasConceptScore W2004768456C62478195 @default.