FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004768594> ?p ?o ?g. }

• W2004768594 endingPage "13917" @default.
• W2004768594 startingPage "13907" @default.
• W2004768594 abstract "Nicotine is a neuroteratogen and is the likely link between maternal cigarette smoking during pregnancy and sudden infant death syndrome (SIDS). Osmotic minipumps were implanted in 5–7 d CF1 pregnant mice to deliver nicotine bitartrate (60 mg Kg −1 day −1 ) or saline (control) solutions for up to 28 d. Prenatal to early postnatal nicotine exposure did not modify the number of newborns per litter or their postnatal growth; however, nicotine-exposed neonates hypoventilated and had reduced responses to hypercarbia (inhalation of air enriched with 10% CO 2 for 20 min) and hypoxia (inhalation of 100% N 2 for 20 s) at postnatal days 0–3 (P0–P3). In contrast, at postnatal day 8, nicotine-exposed neonates were indistinguishable from controls. Isolated brainstem–spinal cord preparations obtained from P0 to P3 nicotine-exposed neonates showed fictive respiration with respiratory cycles longer and more irregular than those of controls, as indicated by high short- and long-term variability in Poincaré plots. In addition, their responses to acidification were reduced, indicating compromise of central chemoreception. Furthermore, the cholinergic contribution to central chemosensory responses switched from muscarinic receptor to nicotinic receptor-based mechanisms. No significant astrogliosis was detectable in the ventral respiratory group of neurons with glial fibrillary acidic protein immunohistochemistry. These results indicate that nicotine exposure affects the respiratory rhythm pattern generator and causes a decline in central chemoreception during early postnatal life. Consequently, breathing would become highly vulnerable, failing to respond to chemosensory demands. Such impairment could be related to the ventilatory abnormalities observed in SIDS." @default.
• W2004768594 created "2016-06-24" @default.
• W2004768594 creator A5000752218 @default.
• W2004768594 creator A5004785517 @default.
• W2004768594 creator A5011503398 @default.
• W2004768594 creator A5019223992 @default.
• W2004768594 creator A5044094653 @default.
• W2004768594 creator A5052945198 @default.
• W2004768594 creator A5066535096 @default.
• W2004768594 creator A5069439442 @default.
• W2004768594 date "2008-12-17" @default.
• W2004768594 modified "2023-10-15" @default.
• W2004768594 title "Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome" @default.
• W2004768594 cites W109096715 @default.
• W2004768594 cites W123264792 @default.
• W2004768594 cites W1482297043 @default.
• W2004768594 cites W1657164559 @default.
• W2004768594 cites W1911973975 @default.
• W2004768594 cites W1953886774 @default.
• W2004768594 cites W1966294098 @default.
• W2004768594 cites W1967583846 @default.
• W2004768594 cites W1970681133 @default.
• W2004768594 cites W1972456437 @default.
• W2004768594 cites W1973922168 @default.
• W2004768594 cites W1979596783 @default.
• W2004768594 cites W1980126183 @default.
• W2004768594 cites W1981538691 @default.
• W2004768594 cites W1983882432 @default.
• W2004768594 cites W1984221287 @default.
• W2004768594 cites W1990574257 @default.
• W2004768594 cites W2006829255 @default.
• W2004768594 cites W2007372251 @default.
• W2004768594 cites W2023364870 @default.
• W2004768594 cites W2025778428 @default.
• W2004768594 cites W2026002815 @default.
• W2004768594 cites W2031218299 @default.
• W2004768594 cites W2036373432 @default.
• W2004768594 cites W2036402431 @default.
• W2004768594 cites W2039008434 @default.
• W2004768594 cites W2039862862 @default.
• W2004768594 cites W2040289750 @default.
• W2004768594 cites W2053411250 @default.
• W2004768594 cites W2063148452 @default.
• W2004768594 cites W2063934168 @default.
• W2004768594 cites W2075396722 @default.
• W2004768594 cites W2076181113 @default.
• W2004768594 cites W2077357336 @default.
• W2004768594 cites W2080909361 @default.
• W2004768594 cites W2087683555 @default.
• W2004768594 cites W2099153552 @default.
• W2004768594 cites W2102750639 @default.
• W2004768594 cites W2108890443 @default.
• W2004768594 cites W2108907303 @default.
• W2004768594 cites W2117947122 @default.
• W2004768594 cites W2118515369 @default.
• W2004768594 cites W2125683116 @default.
• W2004768594 cites W2134627780 @default.
• W2004768594 cites W2142782542 @default.
• W2004768594 cites W2158753003 @default.
• W2004768594 cites W2159519371 @default.
• W2004768594 cites W2164789317 @default.
• W2004768594 cites W2184763406 @default.
• W2004768594 cites W2255521073 @default.
• W2004768594 cites W2328352435 @default.
• W2004768594 cites W4254242752 @default.
• W2004768594 cites W85157149 @default.
• W2004768594 doi "https://doi.org/10.1523/jneurosci.4441-08.2008" @default.
• W2004768594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6671915" @default.
• W2004768594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19091979" @default.
• W2004768594 hasPublicationYear "2008" @default.
• W2004768594 type Work @default.
• W2004768594 sameAs 2004768594 @default.
• W2004768594 citedByCount "76" @default.
• W2004768594 countsByYear W20047685942012 @default.
• W2004768594 countsByYear W20047685942013 @default.
• W2004768594 countsByYear W20047685942014 @default.
• W2004768594 countsByYear W20047685942015 @default.
• W2004768594 countsByYear W20047685942016 @default.
• W2004768594 countsByYear W20047685942017 @default.
• W2004768594 countsByYear W20047685942018 @default.
• W2004768594 countsByYear W20047685942019 @default.
• W2004768594 countsByYear W20047685942020 @default.
• W2004768594 countsByYear W20047685942021 @default.
• W2004768594 countsByYear W20047685942022 @default.
• W2004768594 countsByYear W20047685942023 @default.
• W2004768594 crossrefType "journal-article" @default.
• W2004768594 hasAuthorship W2004768594A5000752218 @default.
• W2004768594 hasAuthorship W2004768594A5004785517 @default.
• W2004768594 hasAuthorship W2004768594A5011503398 @default.
• W2004768594 hasAuthorship W2004768594A5019223992 @default.
• W2004768594 hasAuthorship W2004768594A5044094653 @default.
• W2004768594 hasAuthorship W2004768594A5052945198 @default.
• W2004768594 hasAuthorship W2004768594A5066535096 @default.
• W2004768594 hasAuthorship W2004768594A5069439442 @default.
• W2004768594 hasBestOaLocation W20047685941 @default.
• W2004768594 hasConcept C123792249 @default.
• W2004768594 hasConcept C126322002 @default.
• W2004768594 hasConcept C134018914 @default.

• next