Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004781806> ?p ?o ?g. }
- W2004781806 endingPage "064206" @default.
- W2004781806 startingPage "064206" @default.
- W2004781806 abstract "Temperature-responsive glycopolymer brushes were designed to investigate the effects of grafting architectures of the copolymers on the selective adhesion and collection of hypatocytes. Homo, random and block sequences of N-isopropylacrylamide and 2-lactobionamidoethyl methacrylate were grafted on glass substrates via surface-initiated atom transfer radical polymerization. The galactose/lactose-specific lectin RCA120 and HepG2 cells were used to test for specific recognition of the polymer brushes containing galactose residues over the lower critical solution temperatures (LCSTs). RCA120 showed a specific binding to the brush surfaces at 37 °C. These brush surfaces also facilitated the adhesion of HepG2 cells at 37 °C under nonserum conditions, whereas no adhesion was observed for NIH-3T3 fibroblasts. When the temperature was decreased to 25 °C, almost all the HepG2 cells detached from the block copolymer brush, whereas the random copolymer brush did not release the cells. The difference in releasing kinetics of cells from the surfaces with different grafting architectures can be explained by the correlated effects of significant changes in LCST, mobility, hydrophilicity and mechanical properties of the grafted polymer chains. These findings are important for designing ‘on–off’ cell capture/release substrates for various biomedical applications such as selective cell separation." @default.
- W2004781806 created "2016-06-24" @default.
- W2004781806 creator A5027726678 @default.
- W2004781806 creator A5049846376 @default.
- W2004781806 creator A5052019854 @default.
- W2004781806 creator A5066547166 @default.
- W2004781806 creator A5089591650 @default.
- W2004781806 date "2012-12-01" @default.
- W2004781806 modified "2023-09-23" @default.
- W2004781806 title "Novel temperature-responsive polymer brushes with carbohydrate residues facilitate selective adhesion and collection of hepatocytes" @default.
- W2004781806 cites W148587737 @default.
- W2004781806 cites W1645530958 @default.
- W2004781806 cites W1964453076 @default.
- W2004781806 cites W1964617021 @default.
- W2004781806 cites W1966863664 @default.
- W2004781806 cites W1970581860 @default.
- W2004781806 cites W1972755557 @default.
- W2004781806 cites W1973375556 @default.
- W2004781806 cites W1974772173 @default.
- W2004781806 cites W1982218431 @default.
- W2004781806 cites W1995992975 @default.
- W2004781806 cites W1999785107 @default.
- W2004781806 cites W2004260063 @default.
- W2004781806 cites W2008046073 @default.
- W2004781806 cites W2009522135 @default.
- W2004781806 cites W2009782297 @default.
- W2004781806 cites W2010580129 @default.
- W2004781806 cites W2016722943 @default.
- W2004781806 cites W2017204918 @default.
- W2004781806 cites W2017904896 @default.
- W2004781806 cites W2028421802 @default.
- W2004781806 cites W2030882853 @default.
- W2004781806 cites W2032314943 @default.
- W2004781806 cites W2036612649 @default.
- W2004781806 cites W2040283218 @default.
- W2004781806 cites W2045210602 @default.
- W2004781806 cites W2049889518 @default.
- W2004781806 cites W2050547995 @default.
- W2004781806 cites W2054864661 @default.
- W2004781806 cites W2054997652 @default.
- W2004781806 cites W2055393399 @default.
- W2004781806 cites W2060519237 @default.
- W2004781806 cites W2067345253 @default.
- W2004781806 cites W2071156583 @default.
- W2004781806 cites W2073007613 @default.
- W2004781806 cites W2080855621 @default.
- W2004781806 cites W2082166158 @default.
- W2004781806 cites W2086841672 @default.
- W2004781806 cites W2090787374 @default.
- W2004781806 cites W2092850986 @default.
- W2004781806 cites W2094469836 @default.
- W2004781806 cites W2120949673 @default.
- W2004781806 cites W2134208433 @default.
- W2004781806 cites W2142744987 @default.
- W2004781806 cites W2153485675 @default.
- W2004781806 cites W2156913366 @default.
- W2004781806 cites W2157962256 @default.
- W2004781806 cites W2168414715 @default.
- W2004781806 cites W2338266679 @default.
- W2004781806 doi "https://doi.org/10.1088/1468-6996/13/6/064206" @default.
- W2004781806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5099766" @default.
- W2004781806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27877533" @default.
- W2004781806 hasPublicationYear "2012" @default.
- W2004781806 type Work @default.
- W2004781806 sameAs 2004781806 @default.
- W2004781806 citedByCount "35" @default.
- W2004781806 countsByYear W20047818062013 @default.
- W2004781806 countsByYear W20047818062014 @default.
- W2004781806 countsByYear W20047818062015 @default.
- W2004781806 countsByYear W20047818062016 @default.
- W2004781806 countsByYear W20047818062017 @default.
- W2004781806 countsByYear W20047818062018 @default.
- W2004781806 countsByYear W20047818062019 @default.
- W2004781806 countsByYear W20047818062020 @default.
- W2004781806 countsByYear W20047818062021 @default.
- W2004781806 countsByYear W20047818062022 @default.
- W2004781806 crossrefType "journal-article" @default.
- W2004781806 hasAuthorship W2004781806A5027726678 @default.
- W2004781806 hasAuthorship W2004781806A5049846376 @default.
- W2004781806 hasAuthorship W2004781806A5052019854 @default.
- W2004781806 hasAuthorship W2004781806A5066547166 @default.
- W2004781806 hasAuthorship W2004781806A5089591650 @default.
- W2004781806 hasBestOaLocation W20047818062 @default.
- W2004781806 hasConcept C12554922 @default.
- W2004781806 hasConcept C127413603 @default.
- W2004781806 hasConcept C132050475 @default.
- W2004781806 hasConcept C150539798 @default.
- W2004781806 hasConcept C15920480 @default.
- W2004781806 hasConcept C159985019 @default.
- W2004781806 hasConcept C185592680 @default.
- W2004781806 hasConcept C188027245 @default.
- W2004781806 hasConcept C188109995 @default.
- W2004781806 hasConcept C192562407 @default.
- W2004781806 hasConcept C2775937945 @default.
- W2004781806 hasConcept C2776892847 @default.
- W2004781806 hasConcept C2777231892 @default.
- W2004781806 hasConcept C2781018886 @default.
- W2004781806 hasConcept C42360764 @default.