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- W2004782135 abstract "Effects of the selective inhibitor of cathepsins B and L, Z-Phe-AlaCH2F were studied on the degradation of fibrillar collagen by fibroblasts and osteoclasts in cultured rabbit calvariae at the electron microscopic level. Periosteal fibroblasts from inhibitor-treated explants showed a dose-dependent increase of the volume fraction of vacuoles containing cross-banded collagen fibrils. This was a 7-fold increase over control fibroblasts and the ratio of intracellular and extracellular collagen increased from 2 to 43. The presence of collagen-containing vacuoles was also found in some osteoclasts from inhibitor-treated explants (1 microM or more). The inhibitor appeared to have cytotoxic effects at a concentration of 100 microM. It was concluded that this selective inhibitor exerts its effects intralysosomally in living cells, indicating possibilities for in vivo inhibition of protein degradation." @default.
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- W2004782135 date "1991-07-01" @default.
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- W2004782135 title "Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts" @default.
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- W2004782135 doi "https://doi.org/10.1016/0006-291x(91)91796-f" @default.
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