FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004782456> ?p ?o ?g. }

• W2004782456 endingPage "644" @default.
• W2004782456 startingPage "636" @default.
• W2004782456 abstract "Abstract —Using an in vitro model of a conditionally immortalized cell line, we investigated how human vascular smooth muscle cells (VSMCs) are affected by the expression of simian virus 40 (SV40) large T antigen (LT antigen), which binds to cell cycle regulators, such as the tumor suppressor protein p53. Cells were obtained after infection of saphenous vein–derived VSMCs with a nonreplicative retroviral vector containing a temperature-sensitive (ts) mutant of SV40 LT antigen and were shown to have maintained some characteristics and responses of VSMCs. Under permissive temperature conditions (36°C), the increased rate of cell proliferation was shown to be associated with expression of LT antigen and with LT-antigen binding to and inactivation of p53. p53 inactivation failed to block apoptosis induced by serum withdrawal or by UV irradiation. Downregulation of LT-antigen expression at the nonpermissive temperature (39°C) was shown to be associated with growth arrest, increased expression of the cell cycle inhibitor p21 WAF1/CIP1 , increased MDM2-promoter activity, and differential expression of MDM2 gene products, suggesting that p53-induced transcription/transactivation may be involved in VSMC cell cycle control but not necessarily apoptosis. The established SMC line HVTs-SM1 may be a useful model for the study of processes involved in myointimal hyperplasia and cellular aging, as well as for the study of cell cycle control in general." @default.
• W2004782456 created "2016-06-24" @default.
• W2004782456 creator A5008756563 @default.
• W2004782456 creator A5025139854 @default.
• W2004782456 creator A5053547225 @default.
• W2004782456 creator A5056738653 @default.
• W2004782456 creator A5065179462 @default.
• W2004782456 creator A5073796870 @default.
• W2004782456 date "2000-03-01" @default.
• W2004782456 modified "2023-10-11" @default.
• W2004782456 title "p53, p21 ^WAF1/CIP1 , and MDM2 Involvement in Proliferation and Apoptosis in an In Vitro Model of Conditionally Immortalized Human Vascular Smooth Muscle Cells" @default.
• W2004782456 cites W1591281137 @default.
• W2004782456 cites W1606722513 @default.
• W2004782456 cites W1848078943 @default.
• W2004782456 cites W1980416901 @default.
• W2004782456 cites W1991494214 @default.
• W2004782456 cites W1999997314 @default.
• W2004782456 cites W2013576756 @default.
• W2004782456 cites W2018244552 @default.
• W2004782456 cites W2019961938 @default.
• W2004782456 cites W2026563427 @default.
• W2004782456 cites W2037140131 @default.
• W2004782456 cites W2051848372 @default.
• W2004782456 cites W2052229995 @default.
• W2004782456 cites W2055247766 @default.
• W2004782456 cites W2056530510 @default.
• W2004782456 cites W2061404129 @default.
• W2004782456 cites W2071113103 @default.
• W2004782456 cites W2092342798 @default.
• W2004782456 cites W2099907467 @default.
• W2004782456 cites W2115435531 @default.
• W2004782456 cites W2134871100 @default.
• W2004782456 cites W2137570167 @default.
• W2004782456 cites W2140083987 @default.
• W2004782456 cites W2149287328 @default.
• W2004782456 cites W2149703879 @default.
• W2004782456 cites W2157948874 @default.
• W2004782456 cites W2187381468 @default.
• W2004782456 cites W2189134039 @default.
• W2004782456 doi "https://doi.org/10.1161/01.atv.20.3.636" @default.
• W2004782456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10764661" @default.
• W2004782456 hasPublicationYear "2000" @default.
• W2004782456 type Work @default.
• W2004782456 sameAs 2004782456 @default.
• W2004782456 citedByCount "17" @default.
• W2004782456 countsByYear W20047824562012 @default.
• W2004782456 countsByYear W20047824562017 @default.
• W2004782456 countsByYear W20047824562020 @default.
• W2004782456 crossrefType "journal-article" @default.
• W2004782456 hasAuthorship W2004782456A5008756563 @default.
• W2004782456 hasAuthorship W2004782456A5025139854 @default.
• W2004782456 hasAuthorship W2004782456A5053547225 @default.
• W2004782456 hasAuthorship W2004782456A5056738653 @default.
• W2004782456 hasAuthorship W2004782456A5065179462 @default.
• W2004782456 hasAuthorship W2004782456A5073796870 @default.
• W2004782456 hasBestOaLocation W20047824561 @default.
• W2004782456 hasConcept C104317684 @default.
• W2004782456 hasConcept C105696609 @default.
• W2004782456 hasConcept C127561419 @default.
• W2004782456 hasConcept C1292079 @default.
• W2004782456 hasConcept C134018914 @default.
• W2004782456 hasConcept C147483822 @default.
• W2004782456 hasConcept C153911025 @default.
• W2004782456 hasConcept C190283241 @default.
• W2004782456 hasConcept C203014093 @default.
• W2004782456 hasConcept C2775971809 @default.
• W2004782456 hasConcept C2779395532 @default.
• W2004782456 hasConcept C29537977 @default.
• W2004782456 hasConcept C2992686903 @default.
• W2004782456 hasConcept C502942594 @default.
• W2004782456 hasConcept C54009773 @default.
• W2004782456 hasConcept C54355233 @default.
• W2004782456 hasConcept C55493867 @default.
• W2004782456 hasConcept C62112901 @default.
• W2004782456 hasConcept C81885089 @default.
• W2004782456 hasConcept C86339819 @default.
• W2004782456 hasConcept C86803240 @default.
• W2004782456 hasConcept C95444343 @default.
• W2004782456 hasConceptScore W2004782456C104317684 @default.
• W2004782456 hasConceptScore W2004782456C105696609 @default.
• W2004782456 hasConceptScore W2004782456C127561419 @default.
• W2004782456 hasConceptScore W2004782456C1292079 @default.
• W2004782456 hasConceptScore W2004782456C134018914 @default.
• W2004782456 hasConceptScore W2004782456C147483822 @default.
• W2004782456 hasConceptScore W2004782456C153911025 @default.
• W2004782456 hasConceptScore W2004782456C190283241 @default.
• W2004782456 hasConceptScore W2004782456C203014093 @default.
• W2004782456 hasConceptScore W2004782456C2775971809 @default.
• W2004782456 hasConceptScore W2004782456C2779395532 @default.
• W2004782456 hasConceptScore W2004782456C29537977 @default.
• W2004782456 hasConceptScore W2004782456C2992686903 @default.
• W2004782456 hasConceptScore W2004782456C502942594 @default.
• W2004782456 hasConceptScore W2004782456C54009773 @default.
• W2004782456 hasConceptScore W2004782456C54355233 @default.
• W2004782456 hasConceptScore W2004782456C55493867 @default.
• W2004782456 hasConceptScore W2004782456C62112901 @default.
• W2004782456 hasConceptScore W2004782456C81885089 @default.
• W2004782456 hasConceptScore W2004782456C86339819 @default.

• next